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Titolo:
CLUSTERING OF B-EPITOPES AND T-EPITOPES WITHIN SHORT SEQUENCE REGIONSOF THE NICOTINIC ACETYLCHOLINE-RECEPTOR
Autore:
BELLONE M; KARACHUNSKI PI; OSTLIE N; LEI S; CONTIFINE BM;
Indirizzi:
UNIV MINNESOTA,COLL BIOL SCI,DEPT BIOCHEM,1479 GORTNER AVE ST PAUL MN55108 UNIV MINNESOTA,COLL BIOL SCI,DEPT BIOCHEM ST PAUL MN 55108 UNIV MINNESOTA,SCH MED,DEPT PHARMACOL MINNEAPOLIS MN 55455
Titolo Testata:
Scandinavian journal of immunology
fascicolo: 2, volume: 41, anno: 1995,
pagine: 135 - 140
SICI:
0300-9475(1995)41:2<135:COBATW>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
MAIN IMMUNOGENIC REGION; EXPERIMENTAL MYASTHENIA-GRAVIS; HUMORAL IMMUNE-RESPONSE; ALPHA-SUBUNIT; MONOCLONAL-ANTIBODIES; CELL EPITOPES; ANTIGEN; RECOGNITION; HEMAGGLUTININ; MICE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
37
Recensione:
Indirizzi per estratti:
Citazione:
M. Bellone et al., "CLUSTERING OF B-EPITOPES AND T-EPITOPES WITHIN SHORT SEQUENCE REGIONSOF THE NICOTINIC ACETYLCHOLINE-RECEPTOR", Scandinavian journal of immunology, 41(2), 1995, pp. 135-140

Abstract

The epitope repertoire of B cells, due to their selective ability to process their specific antigen and the potential bias imposed on the resulting peptides by the surface immunoglobulins bound to the antigen,may influence the T-helper repertoire. Immunization of C57B1/6 mice with Torpedo acetylcholine receptor (TAChR) causes experimental autoimmune myasthenia gravis (EAMG). Anti-TAChR CD4(+) cells recognize epitopes within three sequence regions of the TAChR alpha subunit ('dominantepitopes'). Immunization of mice with denatured or synthetic TAChR antigens sensitizes CD4(+) cells to other TAChR sequence regions ('cryptic epitopes'). We investigated here whether clustering of B and T epitopes within the same short sequence segments occurs during the anti-TAChR response, as previously described for the response to hexogenous antigens unrelated to homologous self proteins. Twelve 19-20 residue synthetic sequences of the TAChR alpha, gamma and delta subunits, containing dominant or cryptic CD4(+) epitopes for C57B1/6 mice, were testedfor ability to induce anti-peptide antibody production. C57B1/6 mice were immunized with the individual peptides. Ten peptides stimulated antibody production. Therefore > 80% of these short TAChR sequences also contain B epitopes. Therefore also in the anti-TAChR response leading to EAMG T and B cell epitopes frequently reside within the same short sequence segment.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/09/20 alle ore 08:29:42