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Titolo:
DIFFERENTIAL SITES OF ACTION OF 8OHDPAT, A 5HT1A AGONIST, ON ACTH ANDPRL SECRETION IN THE RAT
Autore:
PAJOT MTB; MOUNIER F; DISCIULLO A; SCHMIDT B; KORDON C;
Indirizzi:
INSERM,U159,UNITE RECH DYNAM SYST NEUROENDOCRINIENS,2TER RUE ALESIA F-75014 PARIS FRANCE INST NEUROBIOL COLOGNE GERMANY
Titolo Testata:
Neuroendocrinology
fascicolo: 2, volume: 61, anno: 1995,
pagine: 159 - 166
SICI:
0028-3835(1995)61:2<159:DSOAO8>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
THYROTROPIN-RELEASING-HORMONE; PROLACTIN SECRETION; SEROTONERGIC STIMULATION; RECEPTOR SUBTYPE; DOPAMINE RELEASE; 5-HT1A RECEPTOR; HYPOTHALAMUS; NEURONS; ACTIVATION; CORTICOSTERONE;
Keywords:
SEROTONIN; SEROTONIN RECEPTORS; 8-HYDROXY-2-(DI-N-PROPYLAMINO) TETRALIN; PARAVENTRICULAR NUCLEUS; RAPHE NUCLEUS; CORTICOTROPIN; PROLACTIN; CORTICOTROPIN RELEASING HORMONE; DOPAMINE; ARCUATE NUCLEUS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
32
Recensione:
Indirizzi per estratti:
Citazione:
M.T.B. Pajot et al., "DIFFERENTIAL SITES OF ACTION OF 8OHDPAT, A 5HT1A AGONIST, ON ACTH ANDPRL SECRETION IN THE RAT", Neuroendocrinology, 61(2), 1995, pp. 159-166

Abstract

We recently obtained evidence that activation of the 5HT1A subtype receptor enhances both plasma ACTH and prolactin (PRL) concentrations inrats. In order to explore the possible neuroanatomical structures involved in this interaction, we examined ACTH and PRL responses to intracerebral infusions of the 5HT1A receptor agonist 8-hydroxy-2-(di-n-propylamino) tetralin (8OHDPAT). In addition we also tested in vitro effects of 8OHDPAT added to the perifusion medium of pituitary cells or ofhypothalamic slices on hormone or neurotransmitter release, respectively. The ACTH response to 8OHDPAT (0.1 mg/kg) was decreased after depletion of endogenous 5HT stores by p-chlorophenylalanine (PCPA) treatment. In contrast, the PRL response was markedly increased under that condition. Infusion of 8OHDPAT (1 mu g/mu l/15 min) into the dorsal raphe nucleus induced a slow elevation of ACTH release but was ineffectiveon PRL secretion while infusion of 8OHDPAT into the PVN induced a moderate elevation of both ACTH and PRL. After bilateral destruction of the PVN, PRL response to 8OHDPAT (0.1 and 0.25 mg/kg) was markedly potentiated. In contrast, PVN-lesioned animals showed a blunted ACTH response to 8OHDPAT. Basal or CRF-stimulated ACTH secretion rates from perifused dispersed adenohypophyseal cells were not affected by 8OHDPAT but the 5HT1A agonist induced a very slight and transient inhibition of PRL release. 8OHDPAT antagonized, in a dose-dependent manner, the K+-induced release of H-3-DA previously taken up in neurons of mediobasal hypothalamic slices. This data suggests that major sites of 5HT1A interaction in PRL and ACTH regulation are located within the CNS and not in the pituitary. ACTH but not PRL control involves presynaptic interactions and autoreceptors in the raphe nuclei as suggested by the blunted response obtained after 5HT depletion by PCPA. Sites of 5HT1A interaction with PRL regulation cannot be definitely identified from our experiments but increased responsiveness to 5HT1A after PVN lesions suggests that this nucleus exerts a negative tone on PRL secretion.

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Documento generato il 30/03/20 alle ore 10:21:11