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Titolo:
BRAIN-TYPE N-GLYCOSYLATION OF ASIALO-TRANSFERRIN FROM HUMAN CEREBROSPINAL-FLUID
Autore:
HOFFMANN A; NIMTZ M; GETZLAFF R; CONRADT HS;
Indirizzi:
GESELL BIOTECHNOL FORSCH MBH,DEPT MOLEC BIOL,MASCHERODER WEG 1 D-38124 BRAUNSCHWEIG GERMANY GESELL BIOTECHNOL FORSCH MBH,DEPT MOLEC BIOL D-38124 BRAUNSCHWEIG GERMANY GESELL BIOTECHNOL FORSCH MBH,DEPT MOLEC & INSTRUMENTAL STRUCT RES D-38124 BRAUNSCHWEIG GERMANY
Titolo Testata:
FEBS letters
fascicolo: 2-3, volume: 359, anno: 1995,
pagine: 164 - 168
SICI:
0014-5793(1995)359:2-3<164:BNOAFH>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN-SERUM TRANSFERRIN; HUMAN SEROTRANSFERRIN; GENE-EXPRESSION; RAT-BRAIN; CARBOHYDRATE UNITS; CHOROID-PLEXUS; GLYCANS; MICROHETEROGENEITY; IDENTIFICATION; CHROMATOGRAPHY;
Keywords:
N-GLYCOSYLATION (BRAIN-TYPE); CEREBROSPINAL FLUID; HUMAN TRANSFERRIN; HUMAN BETA-TRACE PROTEIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
30
Recensione:
Indirizzi per estratti:
Citazione:
A. Hoffmann et al., "BRAIN-TYPE N-GLYCOSYLATION OF ASIALO-TRANSFERRIN FROM HUMAN CEREBROSPINAL-FLUID", FEBS letters, 359(2-3), 1995, pp. 164-168

Abstract

Asialo-transferrin from human cerebrospinal fluid was purified to homogeneity, Investigation of the structural characteristics of its oligosaccharides support our hypothesis of 'brain-type' glycosylation of intrathecally synthesized cerebrospinal fluid proteins, For carbohydratestructural analysis, high-pH anion-exchange chromatography, methylation analysis, liquid secondary ion- and matrix-assisted laser desorption/ ionization mass spectrometry of the permethylated derivatives were used, The major structure turned out to be a complex-type agalactodiantennary oligosaccharide with bisecting N-acetylglucosamine and proximal fucose, Analysis of a second transferrin preparation containing bothasialo- and sialo-transferrin revealed another major glycan species derived from the sialylated transferrin variant which is galactosylatedand lacks bisecting N-acetylglucosamine and fucose.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 21:55:37