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Titolo:
EXPRESSION OF GROUP-II PHOSPHOLIPASE-A2 IN THE HUMAN GASTROINTESTINAL-TRACT
Autore:
NEVALAINEN TJ; GRONROOS JM; KALLAJOKI M;
Indirizzi:
UNIV TURKU,DEPT PATHOL,KIINAMYLLYNKATU 10 SF-20520 TURKU FINLAND UNIV TURKU,DEPT SURG TURKU FINLAND
Titolo Testata:
Laboratory investigation
fascicolo: 2, volume: 72, anno: 1995,
pagine: 201 - 208
SICI:
0023-6837(1995)72:2<201:EOGPIT>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
PANETH CELL FUNCTION; SMOOTH-MUSCLE CELLS; IMMUNOHISTOCHEMICAL LOCALIZATION; INTESTINAL PHOSPHOLIPASE-A2; INTRACELLULAR DIGESTION; RIBONUCLEIC-ACID; GENE-EXPRESSION; SYNOVIAL-FLUID; PURIFICATION; MICROORGANISMS;
Keywords:
IMMUNOHISTOCHEMISTRY; INTESTINAL METAPLASIA; IN SITU HYBRIDIZATION; NORTHERN HYBRIDIZATION; PANETH CELLS; PHOSPHOLIPASE A2;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
32
Recensione:
Indirizzi per estratti:
Citazione:
T.J. Nevalainen et al., "EXPRESSION OF GROUP-II PHOSPHOLIPASE-A2 IN THE HUMAN GASTROINTESTINAL-TRACT", Laboratory investigation, 72(2), 1995, pp. 201-208

Abstract

BACKGROUND: It has been suggested that group II phospholipase A2 (PLA2-II) plays an essential role in inflammation, but the cellular source(s) of the enzyme is(are) largely unknown. EXPERIMENTAL DESIGN: Expression of PLA2-II was analyzed in human gastrointestinal tract at both protein and mRNA levels. Both normal tissues and specimen from patientswith a few different common gastrointestinal disorders were analyzed. RESULTS: Expression of PLA2-II mRNA was seen in the Paneth cells but not in any other cell type of the intestinal tract. Blood vessel wallsshowed PLA2-II immunoreactivity but were negative in in situ hybridization for PLA2-II mRNA. CONCLUSIONS: It was concluded that nonpancreatic group II PLA2 is synthesized and stored by Paneth cells, whereas other cell types of the gastrointestinal tract seem incapable of synthesis of this enzyme. The positive immunoreaction in vascular structures may reflect the entry of circulating PLA2-II into vessel walls rather than local production of the enzyme.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/11/20 alle ore 20:04:03