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Titolo:
K-ADRENOCEPTOR BLOCKADE( BALANCE OF THE QUADRICEPS MUSCLE DURING DYNAMIC EXERCISE WITH AND WITHOUT BETA)
Autore:
GULLESTAD L; HALLEN J; SEJERSTED OM;
Indirizzi:
UNIV OSLO,ULLEVAAL HOSP,INST EXPTL MED RES N-0407 OSLO NORWAY UNIV OSLO,ULLEVAAL HOSP,INST EXPTL MED RES N-0407 OSLO NORWAY NATL INST OCCUPAT HLTH,DEPT PHYSIOL N-0033 OSLO NORWAY
Titolo Testata:
Journal of applied physiology
fascicolo: 2, volume: 78, anno: 1995,
pagine: 513 - 523
SICI:
8750-7587(1995)78:2<513:KBBOTQ>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN SKELETAL-MUSCLE; INTACT PIG HEARTS; MAXIMAL EXERCISE; ADRENERGIC STIMULATION; POTASSIUM FLUXES; PLASMA; BLOOD; PERFORMANCE; FREQUENCY; LACTATE;
Keywords:
BLOOD FLOW; CATECHOLAMINES; EPINEPHRINE; POTASSIUM LOSS; NOREPINEPHRINE; PROPRANOLOL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
34
Recensione:
Indirizzi per estratti:
Citazione:
L. Gullestad et al., "K-ADRENOCEPTOR BLOCKADE( BALANCE OF THE QUADRICEPS MUSCLE DURING DYNAMIC EXERCISE WITH AND WITHOUT BETA)", Journal of applied physiology, 78(2), 1995, pp. 513-523

Abstract

The effect of propranolol (0.15 mg/kg body wt) on K+ fluxes was investigated in seven healthy males performing 8-min two-legged knee-extension exercise at two different powers. K+ concentration was measured inthe femoral vein by a K+-selective electrode, and leg blood flow was measured by the dye-dilution technique. During control bouts, rates ofchange in femoral venous K+ concentration were 38 +/- 10 and 53 +/- 8mu mol.l(-1).s(-1) at onset of exercise (K+ efflux) and -14 +/- 3 and-34 +/- 3 mu mol.l(-1).s(-1) at cessation of exercise (K+ reuptake) at low and high powers, respectively. This mismatch between K+ efflux and reuptake rates fits with the steady-state K+ loss rate of 0.14 +/- 0.04 and 0.32 +/- 0.09 mmol/min. Propranolol raised K+ efflux rate, did not modify K+ reuptake rate or steady-state K+ loss, but caused transiently increased K+ loss rate at the onset of exercise, thus accentuating the rise of arterial K+ concentration. In conclusion, the continuous muscle K+ loss during steady-state exercise with a small muscle mass is not due to lack of catecholamine stimulation, but beta-adrenoceptor blockade increased the Na+-K+ pump lag so that the initial K+ lossat onset of exercise was increased.

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Documento generato il 29/11/20 alle ore 00:56:42