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Titolo:
COGNITIVE PERFORMANCE AFTER PROGRESSION TO AIDS - A LONGITUDINAL-STUDY FROM THE MULTICENTER AIDS COHORT STUDY
Autore:
SELNES OA; GALAI N; BACELLAR H; MILLER EN; BECKER JT; WESCH J; VANGORP W; MCARTHUR JC;
Indirizzi:
MEYER 222,600 N WOLFE ST BALTIMORE MD 21287 JOHNS HOPKINS UNIV BALTIMORE MD 00000 UNIV CALIF LOS ANGELES LOS ANGELES CA 00000 UNIV PITTSBURGH PITTSBURGH PA 00000 NORTHWESTERN UNIV,SCH MED CHICAGO IL 00000
Titolo Testata:
Neurology
fascicolo: 2, volume: 45, anno: 1995,
pagine: 267 - 275
SICI:
0028-3878(1995)45:2<267:CPAPTA>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
NEUROPSYCHOLOGICAL PERFORMANCE; HIV-INFECTION; DEMENTIA COMPLEX; INDIVIDUALS; MANIFESTATIONS; ASSOCIATION; IMPAIRMENT; SPECTRUM; OUTCOMES; MEN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
37
Recensione:
Indirizzi per estratti:
Citazione:
O.A. Selnes et al., "COGNITIVE PERFORMANCE AFTER PROGRESSION TO AIDS - A LONGITUDINAL-STUDY FROM THE MULTICENTER AIDS COHORT STUDY", Neurology, 45(2), 1995, pp. 267-275

Abstract

Objective: To describe changes in cognitive functioning before and after development of an acquired immune deficiency syndrome (AIDS)-defining illness or CD4+ lymphocyte count <200/mm(3) in participants in theMulticenter AIDS Cohort Study. Methods: The study population includedparticipants who either were diagnosed with an AIDS-defining illness (n = 52) or had at least one measurement of CD4+ count <200/mm(3) (n =57) and who had at least four neuropsychological (NP) evaluations, two or more before and two or more after the AIDS diagnosis. A group of subjects with clinical diagnosis of dementia (n = 29) was also included for comparison. The NP test battery included measures of attention, memory, constructional abilities, and psychomotor speed. Longitudinal data analysis, using the generalized estimating equation, was performed separately for each NP measure. Time was measured in months from thedate of clinical AIDS or CD4+ <200/mm(3). Results: Before AIDS, the dementia group showed significant decline (slope different from zero) only on measures of psychomotor speed. For all other measures, there was no evidence of decline in performance before AIDS for the other groups. After development of AIDS, the group with clinical AIDS showed significant decline on psychomotor speed but none on the other cognitive measures. The group with CD4+ <200/mm(3) did not show significant decline on any of the cognitive measures after AIDS. As expected, the dementia group showed significant decline on all measures. Sensory neuropathy was associated with a significant decline in performance on measures of psychomotor speed after AIDS. Antiretroviral therapy was not associated with any measurable changes in NP performance. Conclusion: These results are consistent with previous findings showing no significant decline in cognitive functions before AIDS, unless overt dementia ispresent, and no decline in immunosuppressed subjects who have had no AIDS-defining illness. By contrast, in subjects who have developed clinical AIDS, there is mild decline in fine motor skills but no significant change in other cognitive domains.

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Documento generato il 30/11/20 alle ore 03:25:12