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Titolo:
CONSERVED EXPRESSION OF THE OPIOID GROWTH-FACTOR, [MET(5)]ENKEPHALIN,AND THE ZETA (ZETA)-OPIOID RECEPTOR IN VERTEBRATE CORNEA
Autore:
ZAGON IS; SASSANI JW; ALLISON G; MCLAUGHLIN PJ;
Indirizzi:
PENN STATE UNIV,MILTON S HERSHEY MED CTR,DEPT ANAT & NEUROSCI,500 UNIV DR HERSHEY PA 17033 PENN STATE UNIV,MILTON S HERSHEY MED CTR,DEPT OPHTHALMOL HERSHEY PA 17033 PENN STATE UNIV,MILTON S HERSHEY MED CTR,DEPT PATHOL HERSHEY PA 17033 PENN STATE UNIV,MILTON S HERSHEY MED CTR,PENN LIONS VIS & RES CTR HERSHEY PA 17033
Titolo Testata:
Brain research
fascicolo: 1, volume: 671, anno: 1995,
pagine: 105 - 111
SICI:
0006-8993(1995)671:1<105:CEOTOG>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
ENDOGENOUS OPIOIDS; DNA-SYNTHESIS; BRAIN; RATS; PROENKEPHALIN; ENKEPHALIN; PROLIFERATION; NALTREXONE; SYSTEMS; CELLS;
Keywords:
OPIOID RECEPTOR; EYE; ENKEPHALIN; GROWTH; CELL RENEWAL; ZETA (ZETA) RECEPTOR; EVOLUTION; NEUROPEPTIDE; IMMUNOCYTOCHEMISTRY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
33
Recensione:
Indirizzi per estratti:
Citazione:
I.S. Zagon et al., "CONSERVED EXPRESSION OF THE OPIOID GROWTH-FACTOR, [MET(5)]ENKEPHALIN,AND THE ZETA (ZETA)-OPIOID RECEPTOR IN VERTEBRATE CORNEA", Brain research, 671(1), 1995, pp. 105-111

Abstract

In addition to neuromodulation, endogenous opioids serve as growth factors. The naturally occurring opioid peptide, [Met(5)]enkephalin, termed opioid growth factor (OGF), has been found to be a potent and tonic inhibitor of processes related to growth and renewal, particularly cell proliferation. OGF mediates its actions through the zeta (zeta) opioid receptor. In order to determine if OGF and/or the zeta receptor are present in human corneal epithelium, immunocytochemistry was utilized. Immunoreactivity with regard to OGF and to the zeta receptor couldbe detected in the cortical cytoplasm of both basal and suprabasal epithelial cells, but was not associated with the cell nucleus. Investigation of the ubiquity of OGF and zeta receptor in the vertebrate cornea showed that both elements are present in a wide variety of classes of the phylum Chordata, including mammalia, aves, reptilia, amphibia, and osteichthyes. These results suggest that an endogenous opioid system related to growth may have originated as early as 300 million years ago, and that the function of this system in cellular renewal and homeostasis is a requirement of the vertebrate corneal epithelium.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/09/20 alle ore 15:14:23