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Titolo:
INDUCTION OF EARLY STAGES OF KIDNEY TUBULE DIFFERENTIATION BY LITHIUMIONS
Autore:
DAVIES JA; GARROD DR;
Indirizzi:
UNIV MANCHESTER,SCH BIOL SCI,CANC RES CAMPAIGN EPITHELIAL MORPHOGENESIS RES GR,STOPFORD BLDG MANCHESTER M13 9PT LANCS ENGLAND
Titolo Testata:
Developmental biology
fascicolo: 1, volume: 167, anno: 1995,
pagine: 50 - 60
SICI:
0012-1606(1995)167:1<50:IOESOK>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
METANEPHRIC MESENCHYME; EARLY RESPONSE; GROWTH-FACTOR; EXPRESSION; HOMOLOG; MORPHOGENESIS; INHIBITION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
32
Recensione:
Indirizzi per estratti:
Citazione:
J.A. Davies e D.R. Garrod, "INDUCTION OF EARLY STAGES OF KIDNEY TUBULE DIFFERENTIATION BY LITHIUMIONS", Developmental biology, 167(1), 1995, pp. 50-60

Abstract

Kidney tubules develop by a mesenchyme-epithelium transition, normally induced by ureteric bud through a mechanism that remains obscure. Murine nephrogenesis in vitro has always required heterologous inducing cells. We have discovered that Li+ can elicit the early stages of epithelial differentiation in isolated nephrogenic mesenchyme. We have made detailed comparisons of the timing of morphoregulatory molecule expression between Li+-mediated induction and the traditional in. vitro method using induction by spinal cord. Both followed the same program ofearly morphoregulatory molecule expression, though Li+-induced samples failed to progress into the later parts of the nephrogenic process. Mesenchymes induced by Li+ showed more DNA synthesis than controls, though less than those induced by spinal cord. Discovery of a chemical means to activate differentiation in the absence of heterologous tissueoffers a new basis for studying molecular mechanisms regulating the early events of nephrogenesis, as well as for investigating transduction of inductive signals that initiate the process. (C) 1995 Academic Press, Inc.

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Documento generato il 24/11/20 alle ore 10:10:09