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Titolo:
SELF-AGGREGATION OF PURIFIED AND MEMBRANE-BOUND ERYTHROCYTE CD38 INDUCES EXTENSIVE DECREASE OF ITS ADP-RIBOSYL CYCLASE ACTIVITY
Autore:
ZOCCHI E; FRANCO L; GUIDA L; CALDER L; DEFLORA A;
Indirizzi:
UNIV GENOA,INST BIOCHEM,VIALE BENEDETTO 17 I-16132 GENOA ITALY UNIV GENOA,INST BIOCHEM I-16132 GENOA ITALY ADV BIOTECHNOL CTR I-16132 GENOA ITALY NATL INST MED RES,DIV VIROL LONDON ENGLAND
Titolo Testata:
FEBS letters
fascicolo: 1, volume: 359, anno: 1995,
pagine: 35 - 40
SICI:
0014-5793(1995)359:1<35:SOPAME>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
RECEPTOR DIMERIZATION; CELL ACTIVATION; OUTER SURFACE; ANTIGEN CD38; HYDROLYSIS; MOLECULE; NAD+; METABOLITE; PROTEINS; CALCIUM;
Keywords:
CD38; ERYTHROCYTE; OLIGOMERIZATION; ADP-RIBOSYL CYCLASE; NAD(+) GLYCOHYDROLASE; ENZYME INACTIVATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
22
Recensione:
Indirizzi per estratti:
Citazione:
E. Zocchi et al., "SELF-AGGREGATION OF PURIFIED AND MEMBRANE-BOUND ERYTHROCYTE CD38 INDUCES EXTENSIVE DECREASE OF ITS ADP-RIBOSYL CYCLASE ACTIVITY", FEBS letters, 359(1), 1995, pp. 35-40

Abstract

The transmembrane glycoprotein CD38 is a bifunctional enzyme that catalyzes at its ectocellular domain both the synthesis and the hydrolysis of cyclic ADP-ribose (cADPR). The complete reaction, converting NAD() to nicotinamide and ADP-ribose, reproduces an NAD(+)glycohydrolase (NADase) reaction. CD38 purified from human erythrocyte membranes has been recently shown to undergo stable oligomerization induced by either NAD(+) or beta-mercaptoethanol. We demonstrate that oligomerization is also triggered by reduced glutathione (GSH) and that the GSH-induced self-aggregation of purified CD38 is accompanied by extensive and comparable decrease of its ADP-ribosyl cyclase and NADase activities. GSH-induced oligomerization of CD38 and strong enzyme inactivation take place also in situ on erythrocyte membranes.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/09/20 alle ore 20:10:06