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Titolo:
WHOLE-BODY QUANTITATIVE AUTORADIOGRAPHIC STUDY OF THE BIODISTRIBUTIONOF IOBITRIDOL IN RATS
Autore:
BOURRINET P; DENCAUSSE A; COCHET P; BROMETPETIT M; CHAMBON C;
Indirizzi:
LAB GUERBET,BP 50400 F-95943 ROISSY FRANCE BIOTEC CTR BIOSCI ORLEANS FRANCE
Titolo Testata:
Investigative radiology
fascicolo: 12, volume: 29, anno: 1994,
pagine: 1057 - 1060
SICI:
0020-9996(1994)29:12<1057:WQASOT>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Keywords:
IOBITRIDOL; TISSUE DISTRIBUTION; QUANTITATIVE AUTORADIOGRAPHY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
9
Recensione:
Indirizzi per estratti:
Citazione:
P. Bourrinet et al., "WHOLE-BODY QUANTITATIVE AUTORADIOGRAPHIC STUDY OF THE BIODISTRIBUTIONOF IOBITRIDOL IN RATS", Investigative radiology, 29(12), 1994, pp. 1057-1060

Abstract

RATIONALE AND OBJECTIVES. Iobitridol is a new nonionic low-osmolalitycontrast medium, During preclinical development of this agent, it wasof interest to verify that it behaves like other urographic and angiographic contrast agents (i.e,, as a tracer of extracellular fluid). METHODS. Male and female rats were imaged using a quantitative autoradiographic method after intravenous administration of iodine-125-labeled product at a dose of 300 mg iodine/kg. RESULTS. The radioactivity was rapidly distributed with substantial uptake in the thyroid, kidneys, and skin after 10 minutes, The central nervous system showed no uptake. The radioactivity was rapidly eliminated (i.e,, after 24 and 48 hours, only traces were found) except in the thyroid (because of free radiolabeled iodides present in small quantities in the administered solution). The considerable renal uptake after administration can be attributed to urinary excretion of the radioactivity (86% of the administereddose after 24 hours), Total elimination was achieved after 48 hours. No sex-related effects were observed. CONCLUSION. The absence of a target organ, the abundant and rapid urinary elimination, and the absenceof transfer across the blood-brain barrier suggest that iobitridol isa tracer of extracellular fluid.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/08/20 alle ore 15:40:17