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Titolo:
DIFFERENCES IN RESPONSE OF THYROTROPIN TO 3,5,3'-TRIIODOTHYRONINE AND3,5,3'-TRIIODOTHYROACETIC ACID IN PATIENTS WITH RESISTANCE TO THYROID-HORMONE
Autore:
UEDA S; TAKAMATSU J; FUKATA S; TANAKA K; SHIMIZU N; SAKATA S; YAMAJI T; KUMA K; OHSAWA N;
Indirizzi:
OSAKA MED COLL,DEPT INTERNAL MED 1,2-7 DAIGAKU CHO TAKATSUKI OSAKA 569 JAPAN OSAKA MED COLL,DEPT INTERNAL MED 1 TAKATSUKI OSAKA 569 JAPAN KUMA HOSP KOBE HYOGO 652 JAPAN TEIKYO UNIV,DEPT INTERNAL MED 3 TOKYO 173 JAPAN JOTO CLIN INTERNAL MED GIFU 500 JAPAN UNIV TOKYO,SCH MED,DEPT INTERNAL MED 3 TOKYO 113 JAPAN
Titolo Testata:
Thyroid
fascicolo: 6, volume: 6, anno: 1996,
pagine: 563 - 570
SICI:
1050-7256(1996)6:6<563:DIROTT>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
TSH HYPERSECRETION; PERIPHERAL-TISSUES; BINDING GLOBULIN; ALPHA-SUBUNIT; PITUITARY; SECRETION; THERAPY; HYPERTHYROIDISM; BROMOCRIPTINE; TRIAC;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
22
Recensione:
Indirizzi per estratti:
Citazione:
S. Ueda et al., "DIFFERENCES IN RESPONSE OF THYROTROPIN TO 3,5,3'-TRIIODOTHYRONINE AND3,5,3'-TRIIODOTHYROACETIC ACID IN PATIENTS WITH RESISTANCE TO THYROID-HORMONE", Thyroid, 6(6), 1996, pp. 563-570

Abstract

This study investigated the response of TSH secretion to 3,5,3'-triiodothyronine (T-3) and 3,5,3'-triiodothyroacetic acid (Triac) in patients with resistance to thyroid hormone, and compared the responses withthose in patients with TSH-secreting pituitary adenoma and normal subjects. A short-term administration of 75 mu g of T-3 daily for 7 days suppressed serum TSH concentrations almost completely in normal subjects, but suppressed TSH only partially in patients With resistance to thyroid hormone and TSH-secreting pituitary adenoma. A single-dose administration of 75 mu g of T-3 gave similar results in regard to TSH suppressibility in these three subjects groups. In contrast, a single-dose administration of 1.4 mg of Triac remarkably suppressed serum TSH concentrations after 2 hours in not only normal subjects (-34 +/- 11% [mean +/- SD] from the basal value) but also in patients with resistanceto thyroid hormone (-31 +/- 9%), and this TSH suppression continued for 4 hours. After 24 hours, this TSH suppression persisted in normal subjects (-62 +/- 12%) but was relieved in patients with resistance to thyroid hormone (-23 +/- 14%). After the Triac administration, molar ratios of alpha-subunit to TSH in serum were decreased in patients withTSH-secreting pituitary adenoma but increased in patients with resistance to thyroid hormone. Because the Triac therapy for patients with resistance to thyroid hormone suppressed pituitary-TSH secretion duringthe early phase of drug ingestion, this drug should be given several times within a day to obtain continuous TSH-suppressive effects.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/05/20 alle ore 15:23:55