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Titolo:
BEHAVIORAL VIGILANCE IN RATS - TASK VALIDATION AND EFFECTS OF AGE, AMPHETAMINE, AND BENZODIAZEPINE RECEPTOR LIGANDS
Autore:
MCGAUGHY J; SARTER M;
Indirizzi:
OHIO STATE UNIV,DEPT PSYCHOL,227 TOWNSHEND HALL COLUMBUS OH 43210 OHIO STATE UNIV,DEPT PSYCHOL COLUMBUS OH 43210
Titolo Testata:
Psychopharmacology
fascicolo: 3, volume: 117, anno: 1995,
pagine: 340 - 357
Fonte:
ISI
Lingua:
ENG
Soggetto:
SIGNAL-DETECTION THEORY; BASAL FOREBRAIN; ACETYLCHOLINE-RELEASE; ALZHEIMERS-DISEASE; NUCLEUS BASALIS; SUCCESSIVE DISCRIMINATION; CHOLINERGIC NEURONS; SUSTAINED ATTENTION; COGNITIVE-PROCESSES; INDUCED IMPAIRMENT;
Keywords:
ATTENTION; VIGILANCE; AGE; CHLORIDAZEPOXIDE; ZK 93426; RU 33965; AMPHETAMINE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Physical, Chemical & Earth Sciences
Physical, Chemical & Earth Sciences
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
91
Recensione:
Indirizzi per estratti:
Citazione:
J. Mcgaughy e M. Sarter, "BEHAVIORAL VIGILANCE IN RATS - TASK VALIDATION AND EFFECTS OF AGE, AMPHETAMINE, AND BENZODIAZEPINE RECEPTOR LIGANDS", Psychopharmacology, 117(3), 1995, pp. 340-357

Abstract

An operant task for the measurement of sustained attention or vigilance in rats was characterized. The task requires the animals to respondto the presentation of visual signals (presented for 25, 50, or 500 ms) by operating one lever (''hits'') and to the absence of a signal byoperating the opposite lever (''correct rejection''). Incorrect responses (''misses'' and ''false alarms'', respectively) were not rewarded. Performance in this task is a function of signal length, i.e., the shorter the signals the higher the number of misses. An increase in ''background noise'' by flashing the chamber houselight (at 0.5 Hz) impaired the animals' ability to discriminate between signal and nonsignal events. Also, flashing the houselight augmented the vigilance decrement observed for shortest signals. An increase in the event-rate also resulted in a vigilance decrement. Finally the inability of the animals to time signals was examined by testing the effects of an increase in event asynchrony. In a second experiment, the performance of differently aged rats (6- and 20 month-old male BNNia/F344 rats) was studied. Compared to young animals, 20-month-old rats showed a decrease in theirability to discriminate between shortest signals (25 ms) and non-signal events but did not differ in their ability to correctly reject nonsignal trials. Administration of the benzodiazepine receptor (BZR) agonist chlordiazepoxide (CDP; 3, 5, 8 mg/kg) resulted in an impairment ofthe animals' ability to discriminate between signal and non-signal events and, similar to the effects of age, this effect was exclusively due to an increase in the number of misses. CDP generally produced potent effects while affecting the aged animals to a greater degree. BZR-ligands with weak or ''selective'' inverse agonist properties (ZK 93426; beta-CCtB) did not affect vigilance performance. The BZR partial inverse agonist RU 33965 (0.1, 0.5 mg/kg) dose-dependently impaired vigilance performance. The administration of amphetamine (0.4, 0.8 mg/kg) also impaired performance, but these impairments were possibly based oneffects unrelated to attentional mechanisms. The finding that performance in this task revealed the interactions between the effects of ageand BZR agonists on attentional abilities further supports the validity of measures of performance generated by this task.

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Documento generato il 15/07/20 alle ore 08:25:54