Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
PREVENTION OF ATHEROSCLEROSIS IN APOLIPOPROTEIN E-DEFICIENT MICE BY BONE-MARROW TRANSPLANTATION
Autore:
LINTON MF; ATKINSON JB; FAZIO S;
Indirizzi:
VANDERBILT UNIV,MED CTR N,SCH MED,DEPT MED,DIV ENDOCRINOL,ROOM AA 4206 NASHVILLE TN 37232 VANDERBILT UNIV,MED CTR N,SCH MED,DEPT PATHOL NASHVILLE TN 37232
Titolo Testata:
Science
fascicolo: 5200, volume: 267, anno: 1995,
pagine: 1034 - 1037
SICI:
0036-8075(1995)267:5200<1034:POAIAE>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
HERITABLE HYPERLIPIDEMIC RABBITS; III HYPERLIPOPROTEINEMIA; LIVER-TRANSPLANTATION; DENSITY-LIPOPROTEIN; PLASMA-LIPOPROTEINS; MOUSE MACROPHAGES; APOPROTEIN-E; CELLS; HYPERCHOLESTEROLEMIA; CHOLESTEROL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
38
Recensione:
Indirizzi per estratti:
Citazione:
M.F. Linton et al., "PREVENTION OF ATHEROSCLEROSIS IN APOLIPOPROTEIN E-DEFICIENT MICE BY BONE-MARROW TRANSPLANTATION", Science, 267(5200), 1995, pp. 1034-1037

Abstract

Apolipoprotein E (apoE) deficiency causes severe hyperlipidemia and atherosclerosis in humans and in gene-targeted mice. Although the majority of apoE in plasma is of hepatic origin, apoE is synthesized by a variety of cell types, including macrophages. Because macrophages derive from hematopoietic cells, bone marrow transplantation was used to examine the potential of apoE synthesized by bone marrow-derived cells to correct the hyperlipidemia and atherosclerosis caused by apoE deficiency. After transplantation of bone marrow from mice with the normal apoE gene into apoE-deficient mice, apoE was detected in serum and promoted clearance of lipoproteins and normalization of serum cholesterol levels. ApoE-deficient mice given transplants of normal bone marrow showed virtually complete protection from diet-induced atherosclerosis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 16:10:13