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Titolo:
SELECTIVE SUPPRESSION OF TYPE-B MONOAMINE-OXIDASE IMMUNOREACTIVITY INTHE RAPHE NUCLEI FOLLOWING MPTP ADMINISTRATION IN THE CAT
Autore:
LIN JS; HOU YP; KITAHAMA K; JOUVET M;
Indirizzi:
UNIV LYON 1,DEPT EXPTL MED,CNRS,URA 1195,INSERM U52,8 AV ROCKEFELLER F-69373 LYON 08 FRANCE LAB L LAFON F-94701 MAISONS ALFORT FRANCE
Titolo Testata:
NeuroReport
fascicolo: 2, volume: 6, anno: 1995,
pagine: 321 - 324
SICI:
0959-4965(1995)6:2<321:SSOTMI>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
N-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE MPTP; DOPAMINERGIC NEUROTOXICITY; PARKINSONISM; BRAIN; MPP+; 1-METHYL-4-PHENYL-1,2,5,6-TETRAHYDROPYRIDINE; OXIDATION; NEURONS; SITES; SLEEP;
Keywords:
TYPE B MONOAMINE OXIDASE (MAO-B); MPTP; RAPHE NUCLEI; SEROTONINERGIC NEURON; HISTAMINERGIC NEURON; HYPOTHALAMUS; PARADOXICAL SLEEP; CAT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
22
Recensione:
Indirizzi per estratti:
Citazione:
J.S. Lin et al., "SELECTIVE SUPPRESSION OF TYPE-B MONOAMINE-OXIDASE IMMUNOREACTIVITY INTHE RAPHE NUCLEI FOLLOWING MPTP ADMINISTRATION IN THE CAT", NeuroReport, 6(2), 1995, pp. 321-324

Abstract

USING immunohistochemistry, we investigated in the cat the effects ofMPTP, a Parkinsonian syndrome-inducing substance, on brain type B monoamine oxidase (MAO-B) which is responsible for the conversion of MPTPto its neurotoxic product(MPP(+)). Intraperitoneal administration of MPTP (5 mg kg(-1) daily for 5 days) caused a selective suppression of MAO-B in neurones of the raphe nuclei without affecting hypothalamic MAO-B. Since these effects were accompanied by loss of nigral dopaminergic cells but not of raphe cell bodies or 5-HT immunoreactivity, we suggest that MPTP suppresses raphe MAO-B without destroying its presumedhost serotoninergic neurones and that raphe MAO-B does not appear to be crucial in the MPTP-induced nigral lesion. In addition, the MPTP-induced paradoxical sleep suppression might be related to this raphe MAO-B loss.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/07/20 alle ore 13:14:56