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Titolo:
COMPARISON OF EFFECTS OF ACE-INHIBITION WITH CALCIUM-CHANNEL BLOCKADEON RENAL-DISEASE IN A MODEL COMBINING GENETIC-HYPERTENSION AND DIABETES
Autore:
RUMBLE JR; DOYLE AE; COOPER ME;
Indirizzi:
UNIV MELBOURNE,HEIDELBERG REPATRIAT HOSP,DEPT MED HEIDELBERG VIC 3081AUSTRALIA UNIV MELBOURNE,HEIDELBERG REPATRIAT HOSP,DEPT MED HEIDELBERG VIC 3081AUSTRALIA
Titolo Testata:
American journal of hypertension
fascicolo: 1, volume: 8, anno: 1995,
pagine: 53 - 57
SICI:
0895-7061(1995)8:1<53:COEOAW>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Keywords:
HYPERTENSION; DIABETES; ALBUMINURIA; PERINDOPRIL; LACIDIPINE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
NO
Recensione:
Indirizzi per estratti:
Citazione:
J.R. Rumble et al., "COMPARISON OF EFFECTS OF ACE-INHIBITION WITH CALCIUM-CHANNEL BLOCKADEON RENAL-DISEASE IN A MODEL COMBINING GENETIC-HYPERTENSION AND DIABETES", American journal of hypertension, 8(1), 1995, pp. 53-57

Abstract

The aim of this study was to compare the renal effects of angiotensinconverting enzyme (ACE) inhibition with calcium channel blockade in amodel combining genetic hypertension with diabetes. Streptozotocin diabetes was induced in spontaneously hypertensive rats (SHR). The animals were then randomized to receive no treatment, the ACE inhibitor, perindopril, or the dihydropyridine calcium antagonist lacidipine. Body weight, systolic blood pressure, glycemic control, renal function, andalbumin excretion rate (AER) were assessed serially over the 32-week study period. At week 32 the animals; were killed and glomerular volume was measured. Both antihypertensive regimens significantly reduced systolic blood pressure in diabetic SHR. There was no significant difference in glycemic control, serum creatinine, or glomerular filtration rate among the three groups at week 32. The ACE inhibitor perindopril significantly reduced AER and glomerular hypertrophy over the 32 weeks, whereas the calcium antagonist lacidipine failed to reduce AER or glomerular hypertrophy. Thus, in contrast to the effects of ACE inhibition, calcium channel blockade with lacidipine, despite significantly reducing blood pressure, failed to reduce renal injury in this model. These results support the hypothesis that antihypertensive regimens may differ in their capacity to protect the diabetic kidney, despite similar effects on systemic blood pressure.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/07/20 alle ore 08:07:36