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Titolo:
DOPAMINE IN SCHIZOPHRENIA
Autore:
HIETALA J; SYVALAHTI E;
Indirizzi:
UNIV TURKU,CENT HOSP,DEPT PSYCHIAT,KIINAMYLLYNKATU 4-8 FIN-20520 TURKU FINLAND UNIV TURKU,DEPT PHARMACOL & CLIN PHARMACOL TURKU FINLAND
Titolo Testata:
Annals of medicine
fascicolo: 6, volume: 28, anno: 1996,
pagine: 557 - 561
SICI:
0785-3890(1996)28:6<557:DIS>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON EMISSION TOMOGRAPHY; D2-DOPAMINE RECEPTOR OCCUPANCY; C-11 N-METHYLSPIPERONE; D-2; BINDING; BRAIN; DRUGS; SYMPTOMS; DENSITY; NEUROLEPTICS;
Keywords:
BRAIN; DOPAMINE; NEUROTRANSMISSION; SCHIZOPHRENIA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
43
Recensione:
Indirizzi per estratti:
Citazione:
J. Hietala e E. Syvalahti, "DOPAMINE IN SCHIZOPHRENIA", Annals of medicine, 28(6), 1996, pp. 557-561

Abstract

The DA hypothesis of schizophrenia is one of the oldest biological hypotheses of schizophrenia with many revised versions. However, it is unlikely that any single neurotransmitter hypothesis is able to explainthe biological basis of such a highly heterogenous disorder as schizophrenia in a satisfactory way. Rather, it is evident that the biological vulnerability factors and the 'acute neurophysiology' of schizophrenic symptoms involve a complex set of imbalances or aberrant connections in neuronal circuits in the brain. Dopamine is likely to be one of the transmitter substances involved, as evidenced by recent neuroimaging studies in neuroleptic-naive schizophrenia. Regardless of whether the DA hypothesis of schizophrenia is true or not, the DA hypothesis ofneuroleptic drug action still has a relatively solid basis. The DA D2receptor blockade remains the best characterized clinically useful mechanism of drug action to alleviate psychotic symptoms. The ongoing and future work on the precise role of DA in schizophrenia should focus on first-episode/admission neuroleptic-naive schizophrenic patients. Such studies represent the best opportunity of finding out specific changes in the dopaminergic pathways and relating them in a meaningful way to various dimensions of psychopathology seen in schizophrenic patients.

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Documento generato il 25/01/20 alle ore 19:46:05