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Titolo:
CORRECTION OF BETA-GLUCURONIDASE DEFICIENCY IN MICE BY INTRASPLENIC TRANSPLANTATION OF ISOLATED HEPATOCYTES
Autore:
ILAN Y; SHOUVAL D; GALUN E; FEDER R; ADLER R; YATZIV S;
Indirizzi:
HADASSAH UNIV HOSP,DIV MED,LIVER UNIT,POB 12000 IL-91120 JERUSALEM ISRAEL HADASSAH UNIV HOSP,DEPT PEDIAT IL-91120 JERUSALEM ISRAEL
Titolo Testata:
HEPATOLOGY RESEARCH
fascicolo: 2, volume: 3, anno: 1995,
pagine: 97 - 104
SICI:
1386-6346(1995)3:2<97:COBDIM>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
MICROCARRIER-ATTACHED HEPATOCYTES; LIVER-TRANSPLANTATION; RATS;
Keywords:
HEPATOCYTE TRANSPLANTATION; BETA-GLUCURONIDASE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
20
Recensione:
Indirizzi per estratti:
Citazione:
Y. Ilan et al., "CORRECTION OF BETA-GLUCURONIDASE DEFICIENCY IN MICE BY INTRASPLENIC TRANSPLANTATION OF ISOLATED HEPATOCYTES", HEPATOLOGY RESEARCH, 3(2), 1995, pp. 97-104

Abstract

Correction of enzyme activity was successfully accomplished in beta-glucuronidase deficient C3H/HeJ mice after intrasplenic transplantationof isolated hepatocytes obtained from normal Balb/C donors mice. Enzyme activity increased from a mean of 1.1 +/- 0.2 nmol/h/ml on day 0 to15.8 +/- 3.3 nmol/h/ml on day 55 post-transplantation. Examination ofenzyme activity in liver tissue by repeated liver biopsies revealed an increase in beta-glucuronidase activity from a mean of 1.85 +/- 0.6 nmol/h/mg protein on day 0 up to 42.6 +/- 7.3 nmol/h/mg protein on day35 post-transplantation. beta-Galactosidase and beta-N-acetyl-glucosaminidase activities were not significantly changed throughout the study. Intrasplenic transplantation of hepatocytes isolated from beta-glucuronidase-deficient mice did not induce a significant change in three examined hydrolases. These results suggest that transplantation of isolated hepatocytes may be used as an effective tool for therapy of lysosomal enzyme deficiency in mice.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/21 alle ore 14:58:27