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Titolo:
THE EPSTEIN-BARR-VIRUS TRANSFORMING PROTEIN LMP1 ENGAGES SIGNALING PROTEINS FOR THE TUMOR-NECROSIS-FACTOR RECEPTOR FAMILY
Autore:
MOSIALOS G; BIRKENBACH M; YALAMANCHILI R; VANARSDALE T; WARE C; KIEFF E;
Indirizzi:
HARVARD UNIV,SCH MED,DEPT MICROBIOL & MOLEC GENET,DEPT MED BOSTON MA 02115 UNIV CHICAGO,MARJORIE B KOVLER VIRAL ONCOL LABS,DEPT PATHOL CHICAGO IL 60637 UNIV CALIF RIVERSIDE,DIV BIOMED SCI RIVERSIDE CA 92521
Titolo Testata:
Cell
fascicolo: 3, volume: 80, anno: 1995,
pagine: 389 - 399
SICI:
0092-8674(1995)80:3<389:TETPLE>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
FACTOR TNF RECEPTOR; LYMPHOCYTE GROWTH TRANSFORMATION; MEMBRANE-PROTEIN; CELL-LINES; NASOPHARYNGEAL CARCINOMA; MONOCLONAL-ANTIBODIES; NUCLEAR PROTEIN-2; HODGKINS-DISEASE; B TRANSFORMATION; SOLUBLE FORM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
83
Recensione:
Indirizzi per estratti:
Citazione:
G. Mosialos et al., "THE EPSTEIN-BARR-VIRUS TRANSFORMING PROTEIN LMP1 ENGAGES SIGNALING PROTEINS FOR THE TUMOR-NECROSIS-FACTOR RECEPTOR FAMILY", Cell, 80(3), 1995, pp. 389-399

Abstract

The cytoplasmic C-terminus of Epstein-Barr virus (EBV) latent infection membrane protein 1 (LMP1) is essential for B lymphocyte growth transformation and is now shown to interact with a novel human protein (LMP1-associated protein 1 [LAP1]). LAP1 is homologous to a murine protein, tumor necrosis factor receptor-associated factor 2 (TRAF2), implicated in growth signaling from the p80 TNFR. A second novel protein (EBI6), induced by EBV infection, is the human homolog of a second murine TNFR-associated protein (TRAF1). LMP1 expression causes LAP1 and EBI6 to localize to LMP1 clusters in lymphoblast plasma membranes, and LMP1coimmunoprecipitates with these proteins. LAP1 binds to the p80 TNFR,CD40, and the lymphotoxin-p receptor, while EBI6 associates with the pan TNFR. The interaction of LMP1 with these TNFR family-associated proteins is further evidence for their role in signaling and links LMP1-mediated transformation to signal transduction from the TNFR family.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/07/20 alle ore 21:34:44