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Titolo:
ATYPICAL ALVEOLAR HYPERPLASIA - RELATIONSHIP WITH PULMONARY ADENOCARCINOMA, P53, AND C-ERBB-2 EXPRESSION
Autore:
KERR KM; CAREY FA; KING G; LAMB D;
Indirizzi:
UNIV ABERDEEN,SCH MED,DEPT PATHOL,FORESTERHILL ABERDEEN AB9 2ZD SCOTLAND UNIV EDINBURGH,SCH MED,DEPT PATHOL EDINBURGH EH8 9AG MIDLOTHIAN SCOTLAND
Titolo Testata:
Journal of pathology
fascicolo: 4, volume: 174, anno: 1994,
pagine: 249 - 256
SICI:
0022-3417(1994)174:4<249:AAH-RW>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
ADENOMATOUS HYPERPLASIA; LUNG ADENOCARCINOMAS; PROTEIN EXPRESSION; PERIPHERAL LUNG; SUPPRESSOR GENE; CANCER; SCAR; DYSPLASIAS; NEOPLASIA; CARCINOMA;
Keywords:
LUNG; ATYPICAL ALVEOLAR HYPERPLASIA; ADENOCARCINOMA; ONCOGENES; P53; C-ERBB-2; PREMALIGNANCY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
38
Recensione:
Indirizzi per estratti:
Citazione:
K.M. Kerr et al., "ATYPICAL ALVEOLAR HYPERPLASIA - RELATIONSHIP WITH PULMONARY ADENOCARCINOMA, P53, AND C-ERBB-2 EXPRESSION", Journal of pathology, 174(4), 1994, pp. 249-256

Abstract

Atypical alveolar hyperplasia (AAH) has recently been described in human lungs in association with primary lung cancer, particularly adenocarcinoma. Unlike proximal bronchogenic carcinoma, peripheral (parenchymal) adenocarcinoma of the lung does not have a well-recognized progenitor lesion. Epidemiological, morphometric, and cytofluorometric data in the literature suggest that AAH is a candidate premalignant entity,In this study, 97 AAH lesions were found in lungs resected from 29 patients (1-13 lesions per case, mean 3.5) being treated for presumed carcinoma (25/29 had adenocarcinoma). From a study case-load of 285 adenocarcinoma-bearing lungs, the AAH incidence was 8.8 per cent. Sectionsof 67 AAH lesions from 19 patients were stained using monoclonal antibodies against Ki67 (MIB1), p53 (DO7), and c-erbB-2 (NCL-CB11). Ki67 was expressed in up to 10 per cent of AAH nuclei. Thirty-nine lesions (58 per cent) showed stainable p53 protein, while five (7 per cent) expressed membrane c-erbB-2 oncoprotein. These latter five lesions were all strongly positive for p53, and both p53 and c-erbB-2 staining was associated with increased cellular crowding and pleomorphism in AAH. These data demonstrate that AAH exhibits some genetic changes associatedwith malignancy and thereby support the hypothesis that AAH is premalignant.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 19:33:50