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Titolo:
NEUROBIOLOGY OF WITHDRAWAL MOTIVATION - EVIDENCE FOR 2 SEPARATE AVERSIVE EFFECTS PRODUCED IN MORPHINE-NAIVE VERSUS MORPHINE-DEPENDENT RATS BY BOTH NALOXONE AND SPONTANEOUS WITHDRAWAL
Autore:
BECHARA A; NADER K; VANDERKOOY D;
Indirizzi:
UNIV TORONTO,FAC MED,DEPT ANAT & CELL BIOL,100 COLL ST TORONTO ON M5S1A8 CANADA UNIV TORONTO,FAC MED,DEPT ANAT & CELL BIOL TORONTO ON M5S 1A8 CANADA
Titolo Testata:
Behavioral neuroscience
fascicolo: 1, volume: 109, anno: 1995,
pagine: 91 - 105
SICI:
0735-7044(1995)109:1<91:NOWM-E>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
CONDITIONED PLACE PREFERENCES; PHYSICAL-DEPENDENCE; PRECIPITATED WITHDRAWAL; OPIATE WITHDRAWAL; BETA-ENDORPHIN; LIMBIC SYSTEM; HEROIN REWARD; BRAIN; ADDICTION; BLOCKADE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Physical, Chemical & Earth Sciences
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
59
Recensione:
Indirizzi per estratti:
Citazione:
A. Bechara et al., "NEUROBIOLOGY OF WITHDRAWAL MOTIVATION - EVIDENCE FOR 2 SEPARATE AVERSIVE EFFECTS PRODUCED IN MORPHINE-NAIVE VERSUS MORPHINE-DEPENDENT RATS BY BOTH NALOXONE AND SPONTANEOUS WITHDRAWAL", Behavioral neuroscience, 109(1), 1995, pp. 91-105

Abstract

In drug-naive rats, the rewarding effects of morphine are blocked by lesions of the tegmental pedunculopontine nucleus (TPP), but not by neuroleptics. In dependent rats (chronically treated with morphine), morphine reward is blocked by neuroleptics, but not by TPP lesions. Just as this activation of opiate receptors in naive versus dependent rats produces different mechanisms of reward, this study concludes that reduced opioid activity on these opiate receptors produces different mechanisms of aversion. Neuroleptics blocked the conditioned place aversions produced by naloxone and spontaneous withdrawal in morphine dependent, but not naive, rats, without attenuating the somatic withdrawal syndrome induced by naloxone in dependent rats. The researchers suggest that the aversive effects of endogenous opioid withdrawal in naive rats are mediated by different neural substrates than the aversive effects of exogenous opioid withdrawal in dependent rats.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/07/20 alle ore 21:33:12