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Titolo:
CLINICAL METABOLIC CORRELATIONS IN MULTIPLE SYSTEM ATROPHY - A FLUDEOXYGLUCOSE F-18 POSITRON EMISSION TOMOGRAPHIC STUDY
Autore:
PERANI D; BRESSI S; TESTA D; GRASSI F; CORTELLI P; GENTRINI S; SAVOIARDO M; CARACENI T; FAZIO F;
Indirizzi:
UNIV MILAN,SCI INST H SAN RAFFAELE,DEPT NUCL MED,VIA OLGETTINA 60 I-20132 MILAN ITALY UNIV MILAN,SCI INST H SAN RAFFAELE,DEPT NUCL MED I-20132 MILAN ITALY NATL COUNCIL RES,INST NEUROSCI & BIOIMAGING MILAN ITALY HOSP SAN RAFFAELE,INST SCI MILAN ITALY SCI INST NEUROL CARLO BESTA MILAN ITALY UNIV BOLOGNA,DEPT NEUROL BOLOGNA ITALY
Titolo Testata:
Archives of neurology
fascicolo: 2, volume: 52, anno: 1995,
pagine: 179 - 185
SICI:
0003-9942(1995)52:2<179:CMCIMS>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROGRESSIVE SUPRANUCLEAR PALSY; SHY-DRAGER SYNDROME; F-18 DOPA UPTAKE; STRIATONIGRAL DEGENERATION; PARKINSONS-DISEASE; OLIVOPONTOCEREBELLAR ATROPHY; GLUCOSE-UTILIZATION; AUTONOMIC FAILURE; BLOOD-FLOW; HYPOMETABOLISM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
44
Recensione:
Indirizzi per estratti:
Citazione:
D. Perani et al., "CLINICAL METABOLIC CORRELATIONS IN MULTIPLE SYSTEM ATROPHY - A FLUDEOXYGLUCOSE F-18 POSITRON EMISSION TOMOGRAPHIC STUDY", Archives of neurology, 52(2), 1995, pp. 179-185

Abstract

Objective: To evaluate the regional cerebral metabolic involvement; the relationships among regional brain metabolism, clinical features, and quantitative measures of disease severity; and the patterns of brain involvement that can be related to the different types of onset: striatonigral degeneration vs olivopontocerebellar atrophy. Design: Fludeoxyglucose F 18 positron emission tomography (PET) studies performed in patients with multiple system atrophy (MSA) were evaluated for theirclinical features at the onset of the disease and at the time of the PET study. Cases: Seventeen patients diagnosed as having probable MSA and 10 age-matched controls. Results: The hypometabolism in the putamenpallidum complex and in the cerebellum was the best discriminant for disease classification. The efficacy of levodopa treatment was positively correlated with the metabolic activity of the putamen-pallidum complex. The patients with olivopontocerebellar atrophy type (N=8) had a prevalent hypometabolism in the cerebellum, while the patients with striatonigral degeneration type (N=9) had a prevalent impairment in the pallidum-putamen complex. We demonstrated a negative correlation between (1) severity of parkinsonism and metabolic values of putamen and caudate; (2) severity of cerebellar signs and metabolism in the cerebellum; and (3) autonomic dysfunction and metabolic activity in the thalamus, frontal, and temporal regions, bilaterally. Conclusions: These findings support the selective metabolic reduction in the putamen and cerebellum as a marker of MSA. The clinical/metabolic correlations, demonstrating the expected dependence of extrapyramidal and cerebellar signs by dysfunction of basal ganglia and cerebellum, also support a possible involvement of central nervous system structures in autonomic control.

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Documento generato il 05/04/20 alle ore 19:29:06