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Titolo:
CEREBRAL BLOOD-FLOW DURING MIGRAINE ATTACKS WITHOUT AURA AND EFFECT OF SUMATRIPTAN
Autore:
FERRARI MD; HAAN J; BLOKLAND JAK; ARNDT JW; MINNEE P; ZWINDERMAN AH; PAUWELS EKJ; SAXENA PR;
Indirizzi:
UNIV LEIDEN HOSP,DEPT NEUROL,POB 9600 2300 RC LEIDEN NETHERLANDS UNIV LEIDEN HOSP,DEPT RADIOL & NUCL MED 2300 RC LEIDEN NETHERLANDS UNIV LEIDEN HOSP,DEPT MED STAT 2300 RC LEIDEN NETHERLANDS ERASMUS UNIV ROTTERDAM,FAC MED & HLTH SCI,DEPT PHARMACOL 3000 DR ROTTERDAM NETHERLANDS DUTCH MIGRAINE RES GRP LEIDEN NETHERLANDS
Titolo Testata:
Archives of neurology
fascicolo: 2, volume: 52, anno: 1995,
pagine: 135 - 139
SICI:
0003-9942(1995)52:2<135:CBDMAW>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANTIMIGRAINE DRUG SUMATRIPTAN; XE-133 INHALATION; CLASSIC MIGRAINE; COMMON MIGRAINE; HEADACHE; TOMOGRAPHY; ARTERIES; RECEPTOR; HUMANS; SPECT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
33
Recensione:
Indirizzi per estratti:
Citazione:
M.D. Ferrari et al., "CEREBRAL BLOOD-FLOW DURING MIGRAINE ATTACKS WITHOUT AURA AND EFFECT OF SUMATRIPTAN", Archives of neurology, 52(2), 1995, pp. 135-139

Abstract

Objective: To study regional cerebral blood flow (rCBF) during migraine attacks without aura and after treatment with sumatriptan. Design and Intervention: We performed three technetium Tc99m hexemethyl-propyleneamineoxime single photon emission computed tomography scanning procedures in patients with migraine who participated in a double-blind, placebo-controlled, randomized clinical trial (1) outside an attack, (2) during an attack, and (3) after treatment of the attack with 6 mg ofsubcutaneous sumatriptan. Setting: University hospital. Patients: We studied 20 patients with migraine without aura, 15 of whom were evaluated under all three conditions and five of whom were evaluated under only two conditions. Outcome Measures: The single photon emission computed tomographic images were evaluated semiquantitatively with regard to (1) the degree of asymmetry of the rCBF between the headache side and the nonheadache side and (2) the ratio of the rCBF in regions of interest to the rCBF in two reference areas (cerebellum or frontal cortex). Results: We found no significant rCBF asymmetries outside or duringthe attack or after treatment with sumatriptan, and there were no significant changes of the rCBF ratios during the attack (compared with outside the attack) or after treatment of the attack (compared with during the attack). Conclusion: Migraine attacks without aura and treatment of the attacks with 6 mg of subcutaneous sumatriptan are not associated with detectable focal changes of the rCBF.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 16:04:13