Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
CYP2C19 GENOTYPE AND PHENOTYPE DETERMINED BY OMEPRAZOLE IN A KOREAN POPULATION
Autore:
ROH HK; DAHL ML; TYBRING G; YAMADA H; CHA YN; BERTILSSON L;
Indirizzi:
KAROLINSKA INST,HUDDINGE HOSP,DEPT CLIN PHARMACOL,DIV CLIN PHARMACOL S-14186 HUDDINGE SWEDEN KAROLINSKA INST,HUDDINGE HOSP,DEPT CLIN PHARMACOL,DIV CLIN PHARMACOL S-14186 HUDDINGE SWEDEN INHA UNIV,COLL MED,DEPT PHARMACOL & TOXICOL INCHON SOUTH KOREA
Titolo Testata:
Pharmacogenetics
fascicolo: 6, volume: 6, anno: 1996,
pagine: 547 - 551
SICI:
0960-314X(1996)6:6<547:CGAPDB>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
MEPHENYTOIN HYDROXYLATION DEFICIENCY; S-MEPHENYTOIN; GENETIC-POLYMORPHISM; ORIENTAL SUBJECTS; METABOLISM; JAPANESE; CHINESE; DEBRISOQUIN; CAUCASIANS; URINE;
Keywords:
CYP2C19; OMEPRAZOLE; MEPHENYTOIN; KOREAN; POLYMORPHISM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
19
Recensione:
Indirizzi per estratti:
Citazione:
H.K. Roh et al., "CYP2C19 GENOTYPE AND PHENOTYPE DETERMINED BY OMEPRAZOLE IN A KOREAN POPULATION", Pharmacogenetics, 6(6), 1996, pp. 547-551

Abstract

Omeprazole (20 mg orally) was given to 103 healthy Korean subjects and blood was taken 3 h after administration, The plasma concentration ratio of omeprazole and hydroxyomeprazole, used as an index of CYP2C19 activity, was bimodally distributed, Thirteen subjects (12.6%) were identified as poor metabolizers (PMs) with an omeprazole hydroxylation ratio of 6.95 or higher, Among the 206 CYP2C19 alleles, CYP2C192 and CYP2C193 were found in 43 alleles (21%) and 24 alleles (12%), respectively. Twelve subjects (12%) carried two defect alleles (2/*2, *2/*3 or 3/*3), 43 subjects (42%) were heterozygous for a mutated (*2 or *3)and a wild type (1) allele, and the remaining 48 subjects (47%) werehomozygous for the wild type allele, The distributions of the metabolic ratio between these three genotype groups were significantly different (Kruskal-Wallis test: p < 0.0001), The genotypes of 19 additional Korean PMs has been identified in a previous mephenytoin study, From atotal of 32 PMs, 31 were genotypically PMs by analysis of the CYP2C192 and 3 alleles and only one PM subject was found to be heterozygousfor the 1 and *2 alleles, At present it cannot be judged whether this subject has a defective allele with a so-far unidentified mutation or a true wild type allele, We thus confirm a high incidence (12.6%) ofPMs of omeprazole in Koreans and of the 32 Korean PMs 97% could be identified by the genotype analysis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/01/20 alle ore 14:57:34