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Titolo:
ADVERSE-EFFECTS OF INHALED CORTICOSTEROIDS
Autore:
HANANIA NA; CHAPMAN KR; KESTEN S;
Indirizzi:
UNIV TORONTO,TORONTO HOSP,CTR ASTHMA,399 BATHURST ST,EC-4007 TORONTO ON M5T 2S8 CANADA UNIV TORONTO,TORONTO HOSP,CTR ASTHMA TORONTO ON M5T 2S8 CANADA
Titolo Testata:
The American journal of medicine
fascicolo: 2, volume: 98, anno: 1995,
pagine: 196 - 208
SICI:
0002-9343(1995)98:2<196:AOIC>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
BECLOMETHASONE DIPROPIONATE AEROSOL; PITUITARY-ADRENAL-FUNCTION; LONG-TERM TREATMENT; POSTERIOR SUBCAPSULAR CATARACTS; DECREASES SERUM OSTEOCALCIN; STEROID-DEPENDENT ASTHMA; METERED-DOSE INHALER; BONE TURNOVER; CHILDHOOD ASTHMA; AIRWAY HYPERRESPONSIVENESS;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
186
Recensione:
Indirizzi per estratti:
Citazione:
N.A. Hanania et al., "ADVERSE-EFFECTS OF INHALED CORTICOSTEROIDS", The American journal of medicine, 98(2), 1995, pp. 196-208

Abstract

Inhaled corticosteroids are considered by many to be the anti-inflammatory therapy of choice in adult asthma, given their remarkable efficacy and apparent safety. They are presently being prescribed to more patients, at larger doses, and for longer periods of time than ever before. Oropharyngeal candidiasis and dysphonia are the most commonly recognized adverse effects of therapy, but these topical phenomena cause no significant morbidity and are easily managed. By contrast, there is now increasing concern about the potential systemic effects of inhaledcorticosteroids. These putative effects may include adrenal suppression, bone loss, skin thinning, increased cataract formation, decreased linear growth in children, metabolic changes, and behavioral abnormalities. Changes in adrenal function have been noted in patients using medications such as beclomethasone dipropionate and budesonide in doses exceeding 1,500 mu g/day. The clinical relevance of these changes has yet to be clarified. Several shortterm and cross-sectional studies have also revealed changes in biochemical markers of bone turnover and retrospective studies have found reduced bone density in asthmatics treated regularly with inhaled steroids. Long-term prospective studies assessing bone density changes remain to be done. Although much controversy exists, there is no unequivocal evidence that conventional doses ofinhaled steroids significantly retard bone growth in children. Reports on skin changes, increased cataract formation, and behavioral changes are difficult to interpret because of several confounding factors. Although inhaled steroids should, at the present time, continue to be arecommended therapeutic option to all patients with symptomatic asthma, they should always be used in the lowest dosage compatible with disease control.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/09/20 alle ore 20:15:26