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Titolo:
SERUM ANTIBODY-RESPONSE TO SURFACE-ASSOCIATED MATERIAL FROM PERIODONTOPATHOGENIC BACTERIA
Autore:
MEGHJI S; HENDERSON B; KIRBY A; NEWMAN HN; WILSON M;
Indirizzi:
UNIV LONDON,EASTMAN DENT INST ORAL HLTH CARE SCI,DEPT MICROBIOL,MAXILLOFACIAL SURG RES UNIT LONDON WC1X 8LD ENGLAND UNIV LONDON,EASTMAN DENT INST ORAL HLTH CARE SCI,DEPT PERIODONTOL LONDON WC1X 8LD ENGLAND
Titolo Testata:
FEMS immunology and medical microbiology
fascicolo: 2, volume: 10, anno: 1995,
pagine: 101 - 108
SICI:
0928-8244(1995)10:2<101:SATSMF>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACTINOBACILLUS-ACTINOMYCETEMCOMITANS; BACTEROIDES-GINGIVALIS; PERIODONTAL-DISEASE; PORPHYROMONAS-GINGIVALIS; CAPSULAR MATERIAL; PROTEIN; ASACCHAROLYTICUS; ANTIGENS;
Keywords:
PERIODONTOPATHOGEN; JUVENILE PERIODONTITIS; RAPIDLY PROGRESSIVE PERIODONTITIS; SURFACE-ASSOCIATED MATERIAL; ANTIBODY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
25
Recensione:
Indirizzi per estratti:
Citazione:
S. Meghji et al., "SERUM ANTIBODY-RESPONSE TO SURFACE-ASSOCIATED MATERIAL FROM PERIODONTOPATHOGENIC BACTERIA", FEMS immunology and medical microbiology, 10(2), 1995, pp. 101-108

Abstract

Saline extracts of Actinobacillus actinomycetemcomitans, Porphyromonas gingivalis and Eikenella corrodens contain surface-associated components of these bacteria. It has been shown that these extracts are potent stimulators of bone resorption in vitro. The possibility that the components of these surface-associated materials (SAM) could contributeto the serum immune response in patients with juvenile or adult onsetforms of rapidly progressive periodontitis were investigated by direct binding ELISA. Very high titres of serum IgG antibodies to SAM from A. actinomycetemcomitans were detected in patients with localized juvenile periodontitis (LJP). Patients with adult onset rapidly progressive periodontitis (RPP) had significantly raised antibody levels to SAM from P. gingivalis. Both groups of patients had significantly raised levels of antibodies to SAM from E. corrodens compared with control sera. Thus, not only does solubilized SAM have the capacity to induce bone resorption, but it also contributes to the antigenic load on the immune system in LJP and RPP.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 05:44:24