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Titolo:
ALCOHOL AND ENDOMETRIAL CANCER RISK - FINDINGS FROM AN ITALIAN CASE-CONTROL STUDY
Autore:
PARAZZINI F; LAVECCHIA C; DAVANZO B; MORONI S; CHATENOUD L; RICCI E;
Indirizzi:
IST RIC FARMACOL MARIO NEGRI I-20157 MILAN ITALY UNIV MILAN,OSTET GINECOL CLIN 1 I-20122 MILAN ITALY UNIV MILAN,IST STAT MED & BIOMETRIA I-20133 MILAN ITALY
Titolo Testata:
Nutrition and cancer
fascicolo: 1, volume: 23, anno: 1995,
pagine: 55 - 62
SICI:
0163-5581(1995)23:1<55:AAECR->2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
POPULATION ATTRIBUTABLE RISK; PITUITARY-GONADAL-HORMONES; BREAST-CANCER; BEVERAGE CONSUMPTION; CIGARETTE-SMOKING; SEX-HORMONES; WOMEN; EPIDEMIOLOGY; FEMALES; PLASMA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
31
Recensione:
Indirizzi per estratti:
Citazione:
F. Parazzini et al., "ALCOHOL AND ENDOMETRIAL CANCER RISK - FINDINGS FROM AN ITALIAN CASE-CONTROL STUDY", Nutrition and cancer, 23(1), 1995, pp. 55-62

Abstract

Using data from a case-control study conducted in Northern Italy, we analyzed the relation between alcohol drinking and risk of endometrialcancer. Cases were 726 patients, <75 years of age, admitted to the Ospedale Maggiore (including the 4 largest teaching and general hospitals in the Greater Milan area), the University Obstetrics and GynecologyClinics, and the National Cancer Institute of Milan with histologically confirmed endometrial cancer. Controls were 2,123 nonhysterectomized patients, <75 years of age, admitted for acute nongynecological non-hormone-related nonneoplastic conditions to the same network of hospitals where cases had been identified. When total consumption of all alcoholic beverages was considered, 68.2% of cases and 63.9% of controls were drinkers and 12% of cases and 9.3% of controls reported greater than or equal to 2 drinks/day. Considering total alcohol drinking, the relative risk for alcohol drinkers vs. nondrinkers was 1.3 (95% confidence interval 1.1-1.5), and the RR estimates for subsequent levels of intake were 1.1, 1.4, and 1.6 for women drinking >0 less than or equalto 1, >1 less than or equal to 2 and >2 drinks/day (chi(1)(2) trend 11.33, p < 0.001). The estimates were similar when wine only (which represents the large majority of all alcohol intake in Italy) was considered, whereas data were less informative for beer and spirits intake only. No relation emerged between duration of alcohol consumption and risk of endometrial cancer. These findings suggest a potential link between alcohol drinking and endometrial cancer risk and are, in any case,inconsistent with a protective role of alcohol in endometrial carcinogenesis. However, several inconsistencies in the epidemiological and biologic evidence leave open the question of causality of this association.

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Documento generato il 30/11/20 alle ore 16:30:30