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Titolo:
INVOLVEMENT OF DOPAMINE D-1 RECEPTORS IN PHENCYCLIDINE-INDUCED BEHAVIORAL STIMULATION IN RATS
Autore:
TSUTSUMI T; HIRANO M; MATSUMOTO T; NAKAMURA K; HASHIMOTO K; HONDO H; YONEZAWA Y; TSUKASHIMA A; NAKANE H; UCHIMURA H; NAKAHARA T;
Indirizzi:
HIZEN NATL MENTAL HOSP,CTR EMOTIONAL & BEHAVIORAL DISORDERS KANZAKI 84201 SAGA JAPAN KYUSHU UNIV,FAC SCI,DEPT CHEM,HIGASHI KU FUKUOKA 812 JAPAN
Titolo Testata:
Clinical neuropharmacology
fascicolo: 1, volume: 18, anno: 1995,
pagine: 64 - 71
SICI:
0362-5664(1995)18:1<64:IODDRI>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
INDUCED LOCOMOTOR-ACTIVITY; STEREOTYPED BEHAVIOR; TURNING BEHAVIOR; NUCLEUS ACCUMBENS; D1; ATAXIA; AMPHETAMINE; RELEASE; DRUGS; CATECHOLAMINE-H-3;
Keywords:
PHENCYCLIDINE; DOPAMINE D-1 RECEPTOR; DOPAMINE D-2 RECEPTOR; LOCOMOTOR ACTIVITY; STEREOTYPED BEHAVIOR;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
42
Recensione:
Indirizzi per estratti:
Citazione:
T. Tsutsumi et al., "INVOLVEMENT OF DOPAMINE D-1 RECEPTORS IN PHENCYCLIDINE-INDUCED BEHAVIORAL STIMULATION IN RATS", Clinical neuropharmacology, 18(1), 1995, pp. 64-71

Abstract

The effects of dopamine receptor antagonists on phencyclidine (PCP)-induced behaviors were examined in rats. Acute administration with PCP (7.5 mg/kg i.p.) produced various behavioral changes, such as increases of spontaneous activity, head-weaving, sniffing, rearing, back-pedaling, and ataxia. To determine which dopamine receptor subtypes were involved in mediating the PCP-induced behaviors, SCH 23390 (0.05 and 0.5mg/kg), sulpiride (20 and 100 mg/kg), or haloperidol (0.05 and 0.5 mg/kg) were pretreated 30 min before PCP treatment (7.5 mg/kg). A higherdose of SCH 23390 significantly reduced the increase of spontaneous activity induced by PCP. Both doses of sulpiride did not affect the PCP-induced behaviors. A higher dose of haloperidol decreased the PCP-induced spontaneous activity, whereas a lower dose of haloperidol enhanced the activity. Ketanserin (0.5 and 5 mg/kg) did not alter any PCP-induced behaviors. These results suggest that the D-1, but not D-2, dopamine receptor subtype may be involved in the PCP-induced behavioral abnormality.

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Documento generato il 25/02/20 alle ore 08:18:04