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Titolo:
GONADOTROPIN SURGE-ATTENUATING FACTOR BIOACTIVITY IS PRESENT IN FOLLICULAR-FLUID FROM NATURALLY CYCLING WOMEN
Autore:
FOWLER PA; FAHY U; CULLER MD; KNIGHT PG; WARDLE PG; MCLAUGHLIN EA; CUNNINGHAM P; FRASER M; HULL MGR; TEMPLETON A;
Indirizzi:
UNIV ABERDEEN,DEPT OBSTET & GYNAECOL ABERDEEN AB9 2ZD SCOTLAND UNIV BRISTOL,DEPT OBSTET & GYNAECOL BRISTOL BS2 8EG AVON ENGLAND IMMUNOBIOL RES INST ANNANDALE NJ 08801 UNIV READING,DEPT BIOCHEM & PHYSIOL READING RG6 2AJ BERKS ENGLAND
Titolo Testata:
Human reproduction
fascicolo: 1, volume: 10, anno: 1995,
pagine: 68 - 74
SICI:
0268-1161(1995)10:1<68:GSFBIP>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
SELF-PRIMING ACTION; LUTEINIZING-HORMONE SECRETION; FACTOR GNSAF; STIMULATING-HORMONE; INHIBITING FACTOR; INVITRO; RATS; LHRH; IMMUNONEUTRALIZATION; MONKEYS;
Keywords:
FOLLICULAR FLUID; GNRH; GNSAF; SPONTANEOUS CYCLES; WOMEN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
27
Recensione:
Indirizzi per estratti:
Citazione:
P.A. Fowler et al., "GONADOTROPIN SURGE-ATTENUATING FACTOR BIOACTIVITY IS PRESENT IN FOLLICULAR-FLUID FROM NATURALLY CYCLING WOMEN", Human reproduction, 10(1), 1995, pp. 68-74

Abstract

Rat pituitary monolayer bioassays were used to compare gonadotrophin surge-attenuating factor (GnSAF) bioactivity in follicular fluid from 12 follicles in 10 spontaneously cycling women with that in pooled follicular fluid from women undergoing ovulation induction. Expressed as ED(50)s (mu l follicular fluid/well producing 50% of maximal effect), GnSAF bioactivity was detectable in all spontaneous follicular fluid samples (1.4-33.3 mu l/well) and in follicular fluid from women undergoing ovulation induction (6.8 mu l/well). This GnSAF bioactivity was unaffected by pre-incubation with an inhibin antibody. When the data were grouped according to whether the recovered oocytes fertilized in vitro or not, the fertilized group contained significantly greater GnSAF bioactivity than the unfertilized group (5.3 +/- 1.1 and 14.1 +/- 2.6 mu l/well respectively, P < 0.05). While both inhibin bioactivity (9.7+/- 1.4 and 28.9 +/- 12.1 mu l/well) and immunoreactivity (36.8 +/- 2.2 and 21.0 +/- 3.0 and ng/ml) were also greater (P < 0.01) in the fertilized compared with the unfertilized groups respectively, there wereno other significant differences between the two groups. We conclude that GnSAF is found in follicular fluid from spontaneously cycling women, supporting in-vivo evidence for the involvement of GnSAF in feedback control of the ovary-pituitary axis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 21:45:25