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Titolo:
MECHANISMS OF THE ENHANCED CONTRACTILE RESPONSE TO A LOW CONCENTRATION OF PHORBOL 12,13-DIBUTYRATE IN THORACIC AORTA ISOLATED FROM RATS WITH DIETARY MAGNESIUM-DEFICIENCY
Autore:
SAKAGUCHI H; ANAI N; MIYAMOTO A; ISHIGURO S; NISHIO A;
Indirizzi:
KAGOSHIMA UNIV,FAC AGR,DEPT VET PHARMACOL KAGOSHIMA 890 JAPAN KAGOSHIMA UNIV,FAC AGR,DEPT VET PHARMACOL KAGOSHIMA 890 JAPAN
Titolo Testata:
Japanese Journal of Pharmacology
fascicolo: 1, volume: 67, anno: 1995,
pagine: 9 - 13
SICI:
0021-5198(1995)67:1<9:MOTECR>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROTEIN-KINASE-C; VASCULAR SMOOTH-MUSCLE; CALCIUM CHANNELS; BINDING; INCREASES; ESTER; PHARMACOLOGY; MODULATION; ACTIVATION; ARTERIES;
Keywords:
MG-DEFICIENT RAT; PHORBOL 12,13-DIBUTYRATE; PROTEIN KINASE C; [H-3] PN200-110 BINDING; CA2+ CHANNEL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
28
Recensione:
Indirizzi per estratti:
Citazione:
H. Sakaguchi et al., "MECHANISMS OF THE ENHANCED CONTRACTILE RESPONSE TO A LOW CONCENTRATION OF PHORBOL 12,13-DIBUTYRATE IN THORACIC AORTA ISOLATED FROM RATS WITH DIETARY MAGNESIUM-DEFICIENCY", Japanese Journal of Pharmacology, 67(1), 1995, pp. 9-13

Abstract

The mechanisms underlying the enhanced contractile response to phorbol 12,13-dibutyrate (PDBu) were examined in de-endothelialized thoracicaortas isolated from rats with dietary magnesium (Mg) deficiency. PDBu (1.0 nM)-induced contractions were significantly larger in Mg-deficient rats than in the controls. The contraction was completely inhibited by nifedipine, removal of external Ca2+ or by l-(5-isoquinolinesulfonyl)-2-methylpiperazine (H7). PDBu (1.0 nM) and phorbol 12-myristate 13-acetate (1.0 mu M) significantly decreased the K-D value and increased the B-max for the binding of [H-3]PN200-110 to the aortas. The degree of the decrease in the K-D value was significantly greater in Mg-deficient-rats than in the controls. The PDBu-induced decrease in the K-D value was abolished by H7. These results suggest that activation of protein kinase C by phorbol esters may participate in the activation of L-type Ca2+ channels, which increases both the affinity of [H-3]PN200-110 binding and the magnitude of the external Ca2+-dependent contraction. Dietary Mg-deficiency may enhance these processes.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 21:40:21