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Titolo:
THE EXPRESSION OF TISSUE-TYPE PLASMINOGEN-ACTIVATOR, MATRIX METALLOPROTEASES AND ENDOGENOUS INHIBITORS IN THE CENTRAL-NERVOUS-SYSTEM IN MULTIPLE-SCLEROSIS - COMPARISON OF STAGES IN LESION EVOLUTION
Autore:
CUZNER ML; GVERIC D; STRAND C; LOUGHLIN AJ; PAEMEN L; OPDENAKKER G; NEWCOMBE J;
Indirizzi:
INST NEUROL,MULTIPLE SCLEROSIS LAB,1 WAKEFIELD ST LONDON WC1N 1PJ ENGLAND CATHOLIC UNIV LEUVEN,REGA INST MED RES,LAB MOL IMMUNOL B-3000 LOUVAINBELGIUM
Titolo Testata:
Journal of neuropathology and experimental neurology
fascicolo: 12, volume: 55, anno: 1996,
pagine: 1194 - 1204
SICI:
0022-3069(1996)55:12<1194:TEOTPM>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; MYELIN BASIC-PROTEIN; GELATINASE-B; INFLAMMATORY DEMYELINATION; CEREBROSPINAL-FLUID; MESSENGER-RNA; DEGRADATION; MACROPHAGES; PROTEASES; ARTHRITIS;
Keywords:
METALLOPROTEASES; MULTIPLE SCLEROSIS; PLASMINOGEN ACTIVATOR;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
37
Recensione:
Indirizzi per estratti:
Citazione:
M.L. Cuzner et al., "THE EXPRESSION OF TISSUE-TYPE PLASMINOGEN-ACTIVATOR, MATRIX METALLOPROTEASES AND ENDOGENOUS INHIBITORS IN THE CENTRAL-NERVOUS-SYSTEM IN MULTIPLE-SCLEROSIS - COMPARISON OF STAGES IN LESION EVOLUTION", Journal of neuropathology and experimental neurology, 55(12), 1996, pp. 1194-1204

Abstract

The expression of tissue-type plasminogen activator (t-PA) and a number of metalloproteases as well as plasminogen activator inhibitor-1 (PAI-1) and tissue inhibitor of metalloproteases-1 (TIMP-1) was analyzedin the central nervous system (CNS) of normal control and multiple sclerosis (MS) cases by immunohistopathology. The expression of t-PA wasdetectable only in the blood vessel matrix in control white matter, but positive infiltrating mononuclear cells were also observed in MS white matter and primary lesions. In active plaques this pattern converted to strong positivity of foamy macrophages in areas of demyelination, declining in chronic lesions. In general PAI-1 expression paralleledthat of t-PA. Gelatinase A and B were detected predominantly in astrocytes and microglia throughout normal control white matter, with additional positive mononuclear cells in perivascular cuffs in MS white matter. In the demyelinating lesion there is widespread prominent expression of gelatinase B in reactive astrocytes and macrophages, which persists in astrocytes in the chronic lesion. TIMP-1 was also present in the vessel matrix and in lesional macrophages. These observations on the coexpression of enzymes and inhibitors of the matrix degrading cascade in CNS tissue pinpoint t-PA, a rate-limiting enzyme, and gelatinaseB as therapeutic targets in MS.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/09/20 alle ore 14:03:59