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Titolo:
RENAL ELIMINATION OF CEFTAZIDIME DURING PREGNANCY
Autore:
NATHORSTBOOS J; PHILIPSON A; HEDMAN A; ARVISSON A;
Indirizzi:
KAROLINSKA INST,DANDERYD HOSP,DEPT OBSTET & GYNECOL S-18288 DANDERYD SWEDEN KAROLINSKA INST,DANDERYD HOSP,DEPT INFECT DIS S-18288 DANDERYD SWEDEN HUDDINGE UNIV HOSP,KAROLINSKA INST,DEPT CLIN PHARMACOL HUDDINGE SWEDEN
Titolo Testata:
American journal of obstetrics and gynecology
fascicolo: 1, volume: 172, anno: 1995,
parte:, 1
pagine: 163 - 166
SICI:
0002-9378(1995)172:1<163:REOCDP>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
GLOMERULAR-FILTRATION;
Keywords:
CEFTAZIDIME; PHARMACOKINETICS; GLOMERULAR FILTRATION RATE; PREGNANCY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
14
Recensione:
Indirizzi per estratti:
Citazione:
J. Nathorstboos et al., "RENAL ELIMINATION OF CEFTAZIDIME DURING PREGNANCY", American journal of obstetrics and gynecology, 172(1), 1995, pp. 163-166

Abstract

OBJECTIVE: Our purpose was to study the pharmacokinetics of ceftazidime at different stages of pregnancy and in the nonpregnant state to determine whether glomerular filtration rate is altered and whether tubular secretions occurs. STUDY DESIGN: Twelve pregnant women with asymptomatic bacteruria were given a bolus dose of 400 mg of ceftazidime followed by a constant infusion for 4 hours. Inulin was infused simultaneously to determine glomerular filtration rate. Blood samples were drawn every 30 minutes. Urine was collected immediately after the bolus dose and then every hour. The same study procedure was then repeated twice: 2 weeks before the expected delivery and after termination of breast-feeding. RESULTS: At term clearance values were raised by 50% to 100% compared with the values found in the postpartum period. At all observation points a close correlation between inulin and ceftazidime clearance values were found. CONCLUSION: The results strongly indicate that ceftazidime is excreted exclusively by glomerular filtration with no tubular reabsorbtion. During pregnancy the excretion pattern is unaltered, but renal elimination is increased.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 21:48:49