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Titolo:
ANALYSIS OF THE N-LINKED OLIGOSACCHARIDES OF HUMAN C1S USING ELECTROSPRAY-IONIZATION MASS-SPECTROMETRY
Autore:
PETILLOT Y; THIBAULT P; THIELENS NM; ROSSI V; LACROIX M; CODDEVILLE B; SPIK G; SCHUMAKER VN; GAGNON J; ARLAUD GJ;
Indirizzi:
CEA,INST BIOL STRUCT JEAN PIERRE EBEL,ENZYMOL MOLEC LAB,CNRS,41 AVE MARTYRS F-38027 GRENOBLE FRANCE CEA,INST BIOL STRUCT JEAN PIERRE EBEL,ENZYMOL MOLEC LAB,CNRS F-38027 GRENOBLE FRANCE INST MARINE BIOSCI HALIFAX NS CANADA UNIV SCI & TECHNOL LILLE,CHIM BIOL LAB LILLE FRANCE UNIV CALIF LOS ANGELES,DEPT CHEM & BIOCHEM LOS ANGELES CA 90024
Titolo Testata:
FEBS letters
fascicolo: 3, volume: 358, anno: 1995,
pagine: 323 - 328
SICI:
0014-5793(1995)358:3<323:AOTNOO>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
GAS-LIQUID CHROMATOGRAPHY; COMPLEMENT COMPONENT; METHYL GLYCOSIDES; FACTOR-IX; IDENTIFICATION; ACTIVATION; SEQUENCE; CLR; GLYCOPROTEINS; GLYCOSYLATION;
Keywords:
COMPLEMENT; C1; N-LINKED OLIGOSACCHARIDE; ELECTROSPRAY IONIZATION MASS SPECTROMETRY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
22
Recensione:
Indirizzi per estratti:
Citazione:
Y. Petillot et al., "ANALYSIS OF THE N-LINKED OLIGOSACCHARIDES OF HUMAN C1S USING ELECTROSPRAY-IONIZATION MASS-SPECTROMETRY", FEBS letters, 358(3), 1995, pp. 323-328

Abstract

Information on the structures of the oligosaccharides linked to Asn residues 159 and 391 of the human complement protease C ($) over bar 1swas obtained using mass spectrometric and monosaccharide analyses. Asn(159) is linked to a complex-type biantennary, bisialylated oligosaccharide NeuAc2 Gal2 GlcNAc4 Man3 (molecular mass = 2206 +/- 1). Asn(391) is occupied by either a biantennary, bisialylated oligosaccharide, or a triantennary, trisialylated species NeuAc3 Gal3 GlcNAcS Man3 (molecular mass = 2861 +/- 1), or a fucosylated triantennary, trisialylatedspecies NeuAc3 Gal3 GlcNAc5 Man3 Fuc1 (molecular mass = 3007 +/- 1), in relative proportions of approximately 1:1:1. The carbohydrate heterogeneity at Asn(391) gives rise to three major types of C ($) over bar1s molecules of molecular masses 79,318 +/- 8 (A), 79,971 +/- 8 (B), and 80,131 +/- 8 (C), with an average mass of 79,807 +/- 8. A minor modification, yielding an extra mass of 132 +/- 2, is also detected within positions 1-153.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/07/20 alle ore 03:53:44