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Titolo:
REDUCTION OF THYROXINE UPTAKE INTO CEREBROSPINAL-FLUID AND RAT-BRAIN BY HEXACHLOROBENZENE AND PENTACHLOROPHENOL
Autore:
VANRAAIJ JAGM; FRIJTERS CMG; KONG LWY; VANDENBERG KJ; NOTTEN WRF;
Indirizzi:
TNO,MED BIOL LAB,POB 45 2280 AA RIJSWIJK NETHERLANDS TNO,MED BIOL LAB 2280 AA RIJSWIJK NETHERLANDS ERASMUS UNIV ROTTERDAM,INST PUBL HLTH & SOCIAL MED ROTTERDAM NETHERLANDS TNO,NUTR & FOOD RES INST,DEPT NEUROTOXICOL,DIV TOXICOL 2280 HV RIJSWIJK NETHERLANDS
Titolo Testata:
Toxicology
fascicolo: 1-3, volume: 94, anno: 1994,
pagine: 197 - 208
SICI:
0300-483X(1994)94:1-3<197:ROTUIC>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
THYROID-HORMONE LEVELS; CHOROID-PLEXUS; POLYCHLORINATED BIPHENYL; TRANSTHYRETIN PREALBUMIN; INDUCED PORPHYRIA; MESSENGER-RNA; METABOLITES PENTACHLOROPHENOL; CHLORINATED PHENOLS; BINDING-SITES; VITAMIN-A;
Keywords:
HEXACHLOROBENZENE (HCB); PENTACHLOROPHENOL (PCP); CEREBROSPINAL FLUID (CSF); TRANSTHYRETIN (TTR); THYROXINE (T4); T4-TRANSPORT; BRAIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
56
Recensione:
Indirizzi per estratti:
Citazione:
J.A.G.M. Vanraaij et al., "REDUCTION OF THYROXINE UPTAKE INTO CEREBROSPINAL-FLUID AND RAT-BRAIN BY HEXACHLOROBENZENE AND PENTACHLOROPHENOL", Toxicology, 94(1-3), 1994, pp. 197-208

Abstract

In the present study the effects of hexachlorobenzene (HCB) and the metabolite pentachlorophenol (PCP) were investigated with respect to uptake of thyroxine (T4) into cerebrospinal fluid (CSF) and brain structures of rats. [I-125]T4 was taken up into CSF of control rats by a relatively slow process, reaching a steady state after about 3 h. Both repeated dosing of HCB and single doses of PCP caused decreased uptake of [I-125]T4 into CSF, total brain tissue as well as specific brain structures, such as occipital cortex, thalamus, and hippocampus. AlthoughHCB-treatment caused a build-up of HCB and PCP levels in serum in brain only HCB was present in significant amounts (16% of the serum level). In CSF, both HCB and PCP concentrations were below detection levels. Separate experiments with PCP showed, however, a dose- and time-dependent uptake of PCP into CSF. The present results indicate that PCP and the parent compound HCB are able to affect brain supply of T4. This may have consequences for an adequate development of the brain or proper brain function in adults. The exact mechanisms of interference of PCP and/or HCB in brain uptake of T4 remain to be established.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 20:38:55