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Titolo:
PROTEIN-KINASE-C (PKC)-INDUCED PKC DOWN-REGULATION - ASSOCIATION WITHUP-REGULATION OF VESICLE TRAFFIC
Autore:
GOODE NT; HAJIBAGHERI MAN; PARKER PJ;
Indirizzi:
UNIV LONDON ROYAL COLL VET SURG,DEPT VET BASIC SCI,ROYAL COLL ST LONDON NW1 0TU ENGLAND IMPERIAL CANC RES FUND,ELECTRON MICROSCOPY UNIT LONDON WC2A 3PX ENGLAND IMPERIAL CANC RES FUND,PROT PHOSPHORYLAT LAB LONDON WC2A 3PX ENGLAND
Titolo Testata:
The Journal of biological chemistry
fascicolo: 6, volume: 270, anno: 1995,
pagine: 2669 - 2673
SICI:
0021-9258(1995)270:6<2669:P(PD-A>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
MOLECULAR GENETIC-ANALYSIS; SCHIZOSACCHAROMYCES-POMBE; FISSION YEAST; GH4C1 CELLS; ACTIVATION; ZETA; ISOZYMES; GAMMA; ALPHA; PURIFICATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
37
Recensione:
Indirizzi per estratti:
Citazione:
N.T. Goode et al., "PROTEIN-KINASE-C (PKC)-INDUCED PKC DOWN-REGULATION - ASSOCIATION WITHUP-REGULATION OF VESICLE TRAFFIC", The Journal of biological chemistry, 270(6), 1995, pp. 2669-2673

Abstract

Phorbol esters cause long term activation of protein kinase C (PKC) and frequently the down-regulation of PKC protein levels in mammalian cells. Mammalian PKC-gamma, -delta, and -eta down-regulate in response to phorbol esters when expressed in Schizosaccharomyces pombe. However, PKC-epsilon does not down-regulate in S. pombe, in contrast to the behavior of this isotype in mammalian cells. Go-expression of PKC-gammaor -delta with PKC-epsilon in S. pombe renders PKC-epsilon susceptible to down-regulation. A protein kinase defective form of PKC-delta does not downregulate efficiently in S. pombe but, like PKC-epsilon, is susceptible when co-expressed with PKC-gamma or full-length PKC-delta. Thus, down-regulation is a consequence of the catalytic function of certain PKC isotypes with other isotypes being affected in trans, PKC down-regulation parallels a striking accumulation of Vesicles in S. pombe, suggesting a direct relationship between these events.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/09/20 alle ore 11:11:11