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Titolo:
CIRCADIAN VARIATIONS IN ANTIGEN-SPECIFIC PROLIFERATION OF HUMAN T-LYMPHOCYTES AND CORRELATION TO CORTISOL PRODUCTION
Autore:
HIEMKE C; BRUNNER R; HAMMES E; MULLER H; ZUMBUSCHENFELDE KHM; LOHSE AW;
Indirizzi:
UNIV MAINZ,DEPT PSYCHIAT,UNTERE ZAHLBACHER STR 8 D-55131 MAINZ GERMANY UNIV MAINZ,DEPT INTERNAL MED D-55131 MAINZ GERMANY
Titolo Testata:
Psychoneuroendocrinology
fascicolo: 3, volume: 20, anno: 1995,
pagine: 335 - 342
SICI:
0306-4530(1995)20:3<335:CVIAPO>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
PERIPHERAL-BLOOD; GLUCOCORTICOID RECEPTORS; IMMUNE-RESPONSE; CELL; SUBPOPULATIONS; RHYTHMS;
Keywords:
T-CELL PROLIFERATION; DIURNAL VARIATION; TETANUS TOROID; PHYTOHEMAGGLUTININ; CORTISOL; IMMUNOMODULATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
23
Recensione:
Indirizzi per estratti:
Citazione:
C. Hiemke et al., "CIRCADIAN VARIATIONS IN ANTIGEN-SPECIFIC PROLIFERATION OF HUMAN T-LYMPHOCYTES AND CORRELATION TO CORTISOL PRODUCTION", Psychoneuroendocrinology, 20(3), 1995, pp. 335-342

Abstract

Cortisol is a well-known immunosuppressant when used therapeutically. The present investigation was set out to study if diurnal Variations in endogenous cortisol production are reflected by changes in proliferative responses of human lymphocytes to either a mitogen (phytohemagglutinin-A, PHA) or an antigen (tetanus toroid, TT) stimulus. The study included eight healthy volunteers. Blood was withdrawn at 0200, 0600, 1000, and 1800h for preparation of lymphocytes and determination of cortisol in plasma. Isolated cells were incubated without (baseline activity) or with inclusion of either 1 mu g PHA or 10 mu g TT. Proliferation was measured by labelling with H-3-thymidine for 16 h of culture. The cortisol plasma levels exhibited the well known diurnal variationswith highest concentrations at 1000h and lowest levels at 0200h. Baseline activity or PHA stimulated cell proliferation did not show significant diurnal fluctuations. The response to TT, however, decreased by 38% between 0600 and 1000h (p = .01). Correlation analyses revealed that the reduction of the proliferative responses to TT correlated significantly (p < .05) with increases in cortisol plasma levels. It was concluded that diurnal fluctuations in the production of endogenous cortisol might be relevant for daytime dependent variations in immune responsiveness.

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Documento generato il 25/01/20 alle ore 18:52:42