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Titolo:
CLASSICAL SELENIUM-DEPENDENT GLUTATHIONE-PEROXIDASE EXPRESSION IS DECREASED SECONDARY TO IRON-DEFICIENCY IN RATS
Autore:
MORIARTY PM; PICCIANO MF; BEARD JL; REDDY CC;
Indirizzi:
PENN STATE UNIV,GRAD PROGRAM NUTR UNIVERSITY PK PA 16802 PENN STATE UNIV,GRAD PROGRAM NUTR UNIVERSITY PK PA 16802 PENN STATE UNIV,COLL HLTH & HUMAN DEV,DEPT NUTR UNIVERSITY PK PA 16802 PENN STATE UNIV,DEPT VET SCI UNIVERSITY PK PA 16802
Titolo Testata:
The Journal of nutrition
fascicolo: 2, volume: 125, anno: 1995,
pagine: 293 - 301
SICI:
0022-3166(1995)125:2<293:CSGEID>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
MESSENGER-RNA; TRANSFERRIN RECEPTOR; LIVER; SELENOCYSTEINE; IDENTIFICATION; PROTEINS; CODON; CELLS; SITE;
Keywords:
IRON DEFICIENCY; GLUTATHIONE PEROXIDASE; SELENIUM; RATS; GENE EXPRESSION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
31
Recensione:
Indirizzi per estratti:
Citazione:
P.M. Moriarty et al., "CLASSICAL SELENIUM-DEPENDENT GLUTATHIONE-PEROXIDASE EXPRESSION IS DECREASED SECONDARY TO IRON-DEFICIENCY IN RATS", The Journal of nutrition, 125(2), 1995, pp. 293-301

Abstract

While there are reports that classical selenium-dependent glutathioneperoxidase (Se-GPX1) activity is decreased during iron deficiency, the relationship between tissue iron status and Se-GPX1 activity remainsspeculative. This study was undertaken to investigate the mechanism for the decrease in Se-GPX1 activity during iron deficiency. Male weanling Sprague-Dawley rats were given free access to either an iron-deficient or an iron-adequate diet for eight weeks, after which blood, livers, kidneys, hearts, brains and testes were surgically excised. Duringiron deficiency, Se-GPX1 mRNA levels in liver tissue were decreased by approximately 55%. Similarly, the concentration of immunoreactive Se-GPX1 protein and total selenium-dependent glutathione peroxidase (Se-GPX) activity were decreased by 55% and 60%, respectively. In kidney, heart and brain total Se-GPX activities were depressed as much as 33%. Selenium concentration in liver was reduced by 42%, whereas the decrease in Se concentrations in kidney, heart, and brain ranged from 17 to25%. Concentrations of plasma Se also were reduced by 18%, but testesshowed little change in either Se-GPX activity or Se concentration during iron deficiency. Results suggest that the synthesis of Se-GPX1 protein is decreased during iron deficiency possibly due to pretranslational regulation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/09/20 alle ore 13:37:24