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Titolo:
REGIONAL ALTERATIONS OF DOPAMINE AND ITS METABOLITES IN RAT-BRAIN FOLLOWING PORTACAVAL ANASTOMOSIS
Autore:
BERGERON M; SWAIN MS; READER TA; BUTTERWORTH RF;
Indirizzi:
HOP ST LUC,ANDRE VIALLET CLIN RES CTR,NEUROSCI RES UNIT,1058 ST DENISST MONTREAL PQ H2X 3J4 CANADA HOP ST LUC,ANDRE VIALLET CLIN RES CTR,NEUROSCI RES UNIT MONTREAL PQ H2X 3J4 CANADA UNIV MONTREAL,DEPT PHYSIOL MONTREAL PQ H3C 3J7 CANADA UNIV MONTREAL,DEPT PSYCHIAT MONTREAL PQ H3C 3J7 CANADA UNIV MONTREAL,DEPT MED MONTREAL PQ H3C 3J7 CANADA
Titolo Testata:
Neurochemical research
fascicolo: 1, volume: 20, anno: 1995,
pagine: 79 - 86
SICI:
0364-3190(1995)20:1<79:RAODAI>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
PORTAL-SYSTEMIC ENCEPHALOPATHY; CHAIN AMINO-ACIDS; HEPATIC-ENCEPHALOPATHY; CIRRHOTIC-PATIENTS; MONOAMINE METABOLISM; SHUNTED RATS; AMMONIA; SEROTONIN; TISSUE; HIPPOCAMPUS;
Keywords:
PORTACAVAL ANASTOMOSIS; HEPATIC ENCEPHALOPATHY; PORTAL-SYSTEMIC ENCEPHALOPATHY; AMMONIA; DOPAMINE; EXTRAPYRAMIDAL SYMPTOMS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
47
Recensione:
Indirizzi per estratti:
Citazione:
M. Bergeron et al., "REGIONAL ALTERATIONS OF DOPAMINE AND ITS METABOLITES IN RAT-BRAIN FOLLOWING PORTACAVAL ANASTOMOSIS", Neurochemical research, 20(1), 1995, pp. 79-86

Abstract

Hyperammonemia and changes in brain monoamine metabolism have been proposed to contribute to the pathogenesis of the neuropsychiatric symptoms characteristic of human portal-systemic encephalopathy (PSE) resulting from chronic liver disease. Portacaval anastomosis (PCA) in the rat leads to sustained hyperammonemia and mild encephalopathy. In orderto evaluate the role of dopamine (DA) metabolism in PSE, levels of DAand its metabolites were measured by HPLC with electrochemical detection in brain regions of rats with PCA at various stages of encephalopathy precipitated by ammonium acetate administration. Following ammonium acetate administration, rats with PCA rapidly develop severe neurological signs of encephalopathy progressing through loss of righting reflex to coma; sham-operated control animals administered ammonium acetate showed no such neurological deterioration. Concentrations of the DAmetabolites DOPAC and HVA as well as [DA metabolites]/[DA] ratios, anindirect measure of DA turnover in brain, were increased in caudate-putamen, in cingulate and pyriform entorhinal cortices as well as in raphe nucleus and locus coeruleus. Increased DA metabolites, however, did not worsen at coma stages of PSE. Increased DA turnover thus appearsto relate to early neuropsychiatric and extrapyramidal symptoms of PSE.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/01/20 alle ore 12:40:40