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Titolo:
PHYLLANTHUS AMARUS DOWN-REGULATES HEPATITIS-B VIRUS MESSENGER-RNA TRANSCRIPTION AND REPLICATION
Autore:
LEE CD; OTT M; THYAGARAJAN SP; SHAFRITZ DA; BURK RD; GUPTA S;
Indirizzi:
ALBERT EINSTEIN COLL MED,DEPT PEDIAT,LIVER RES CTR,ULLMAN 625,1300 MORRIS PK AVE BRONX NY 10461 ALBERT EINSTEIN COLL MED,DEPT PEDIAT,LIVER RES CTR BRONX NY 10461 DR ALM POSTGRAD INST BASIC MED SCI,DEPT MED,MARION BESSIN LIVER RES CTR MADRAS TAMIL NADU INDIA DR ALM POSTGRAD INST BASIC MED SCI,DEPT MED,DIV GASTROENTEROL MADRAS TAMIL NADU INDIA DR ALM POSTGRAD INST BASIC MED SCI,DEPT MICROBIOL MADRAS TAMIL NADU INDIA ALBERT EINSTEIN COLL MED,DEPT MICROBIOL & IMMUNOL BRONX NY 10461 ALBERT EINSTEIN COLL MED,DEPT OBSTET & GYNECOL BRONX NY 10461
Titolo Testata:
European journal of clinical investigation
fascicolo: 12, volume: 26, anno: 1996,
pagine: 1069 - 1076
SICI:
0014-2972(1996)26:12<1069:PADHVM>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
LIVER-TRANSPLANTATION; SURFACE-ANTIGEN; INFECTION; INVITRO; INVIVO; GENE; MADERASPATENSIS; EXPRESSION; CARRIERS; FAILURE;
Keywords:
GENE EXPRESSION; HEPATITIS B VIRUS; LIVER; MEDICINAL PLANTS; TRANSGENIC MOUSE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
40
Recensione:
Indirizzi per estratti:
Citazione:
C.D. Lee et al., "PHYLLANTHUS AMARUS DOWN-REGULATES HEPATITIS-B VIRUS MESSENGER-RNA TRANSCRIPTION AND REPLICATION", European journal of clinical investigation, 26(12), 1996, pp. 1069-1076

Abstract

The Phyllanthus amarus plant shows potential for treating hepatitis Bvirus. To define the mechanism of action of P. amarus, we used HepG2 2.2.15 cells, which support hepatitis B virus replication. P. amarus inhibited hepatitis B virus polymerase activity, decreased episomal hepatitis B virus DNA content and suppressed virus release into culture medium. To examine transcriptional control mechanisms, we used G26 hepatitis B virus transgenic mice, which produce serum HBsAg but neither HBcAg nor virion particles. When P. amarus was administered to transgenic mice, hepatic HBsAg mRNA levels decreased, indicating transcriptional or post-transcriptional down-regulation of the transgene. Increase in hepatitis B virus mRNA expression after stimulation of the glucocorticoid responsive element was also suppressed by P. amarus, suggestinginvolvement of the hepatitis B virus enhancer in this response. Disruption by P. amarus of hepatitis B virus polymerase activity, mRNA transcription and replication supports its role as an antiviral agent.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/01/21 alle ore 06:14:00