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Titolo:
REVERSIBLE MODIFICATION OF GABA(A) RECEPTOR SUBUNIT MESSENGER-RNA EXPRESSION DURING TOLERANCE TO DIAZEPAM-INDUCED COGNITION DYSFUNCTION
Autore:
LONGONE P; IMPAGNATIELLO F; GUIDOTTI A; COSTA E;
Indirizzi:
UNIV ILLINOIS,DEPT PSYCHIAT,INST PSYCHIAT,1601 W TAYLOR ST CHICAGO IL60612 UNIV ILLINOIS,DEPT PSYCHIAT,INST PSYCHIAT CHICAGO IL 60612
Titolo Testata:
Neuropharmacology
fascicolo: 9-10, volume: 35, anno: 1996,
pagine: 1465 - 1473
SICI:
0028-3908(1996)35:9-10<1465:RMOGRS>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITIVE ALLOSTERIC MODULATOR; CEREBELLAR GRANULE CELLS; ONE-TRIAL TEST; MESSENGER-RNAS; BENZODIAZEPINE LIGANDS; FLURAZEPAM TREATMENT; RAT HIPPOCAMPUS; MEMORY; ACID; IMIDAZENIL;
Keywords:
BENZODIAZEPINE; GABA(A) RECEPTORS; SUBUNIT MESSENGER RNA; COGNITIVE DISRUPTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
57
Recensione:
Indirizzi per estratti:
Citazione:
P. Longone et al., "REVERSIBLE MODIFICATION OF GABA(A) RECEPTOR SUBUNIT MESSENGER-RNA EXPRESSION DURING TOLERANCE TO DIAZEPAM-INDUCED COGNITION DYSFUNCTION", Neuropharmacology, 35(9-10), 1996, pp. 1465-1473

Abstract

Benzodiazepines (BZs) that are endowed with full positive allosteric modulatory (FAM) activity on GABA(A) receptors cause anterograde amnesia in both animals and humans. In rats subjected to a delayed object recognition test, diazepam, endowed with FAM activity, exerted an amnesic action, whereas BZs endowed with partial allosteric modulatory (PAM) activity on GABA(A) receptors, such as imidazenil, failed to induce amnesia, even if administered at doses five times higher than those equipotent to a standard anticonvulsant dose of diazepam (17.6 mu mol/kg/os). After discontinuation of 14 days' treatment with vehicle, diazepam, or imidazenil.(three times daily with increasing doses starting from 17.6 mu mol/kg/os for diazepam and 2.5 mu mol/kg/os for imidazenil), we compared the persistence of tolerance to the amnesic effect of diazepam with the persistence of the changes in the content of four (alpha 1, alpha(5), gamma(2L), gamma(2S)) GABA(A) receptor subunit mRNAs in the fronto-parietal motor (FrPaM) cortex and the hippocampus. Rats receiving the long-term treatment with diazepam developed a tolerance to the amnesic effect of this drug and showed a decrease (30-50%) in the expression of mRNAs encoding for alpha(1), gamma(2L), gamma(2S) GABA(A) receptor subunits, an increase, by approximately 30%, of the expression of mRNA of the alpha(5) subunit in the FrPaM cortex and a decrease, by approximately 25%, in the expression of mRNA, of the alpha(1) subunit in the hippocampus. These changes of subunit mRNA expression and the tolerance to the amnesic effect of diazepam returned to control values 72 hr after termination of the longterm treatment with diazepam. No tolerance to the amnesic effect of diazepam and no changes in GABA(A) receptor subunit mRNA expression were found in rats undergoing long-term treatment with imidazenil. Copyright (C) 1996 Elsevier ScienceLtd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 04:26:05