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Titolo:
EFFECTS OF MYOCARDIAL WATER EXCHANGE ON T-1 ENHANCEMENT DURING BOLUS ADMINISTRATION OF MR CONTRAST AGENTS
Autore:
JUDD RM; ATALAY MK; ROTTMAN GA; ZERHOUNI EA;
Indirizzi:
JOHNS HOPKINS UNIV,143 MRI BLDG,600 N WOLFE ST BALTIMORE MD 21287 JOHNS HOPKINS MED INST BALTIMORE MD 21205
Titolo Testata:
Magnetic resonance in medicine
fascicolo: 2, volume: 33, anno: 1995,
pagine: 215 - 223
SICI:
0740-3194(1995)33:2<215:EOMWEO>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
SIGNAL INTENSITY; VASCULAR VOLUME; BLOOD-VOLUME; PERFUSION; SUSCEPTIBILITY; DEPENDENCE; RELAXATION;
Keywords:
MYOCARDIAL PERFUSION; MAGNETIC RESONANCE; CONTRAST AGENTS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
27
Recensione:
Indirizzi per estratti:
Citazione:
R.M. Judd et al., "EFFECTS OF MYOCARDIAL WATER EXCHANGE ON T-1 ENHANCEMENT DURING BOLUS ADMINISTRATION OF MR CONTRAST AGENTS", Magnetic resonance in medicine, 33(2), 1995, pp. 215-223

Abstract

Interpretation of first-pass myocardial perfusion studies employing bolus administration of T-1 magnetic resonance (MR) contrast agents requires an understanding of the relationship between contrast concentration and image pixel intensity. The potential effects of myocardial water exchange rates among the intravascular, interstitial, and cellular compartments on this relationship are controversial. We directly studied these issues in isolated, nonbeating canine interventricular septa. Myocardial T-1 was measured three times/s during bolus transit of intravascular (albumin-Gd-DTPA and polylysine-Gd-DTPA) and extracellular (gadoteridol) contrast agents. For polylysine-Gd-DTPA, the peak changes in myocardial 1/T-1 (Delta R1) scaled nonlinearly with perfusate contrast concentration whereas a linear relationship would be expected for fast water exchange among the vascular, interstitial, and cellular compartments. For all agents, the peak Delta R1 were much smaller than the values expected on the basis of fast myocardial water exchange. The data demonstrate that in isolated myocardial tissue, myocardial T-1 enhancement during bolus administration of contrast can be strongly affected by myocardial water exchange for both intravascular and extracellular MR contrast agents.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 15:49:42