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Titolo:
BIRTH COHORT AND FAMILIAL RISK OF EPILEPSY - THE EFFECT OF DIMINISHEDRECALL IN STUDIES OF LIFETIME PREVALENCE
Autore:
OTTMAN R; LEE JH; HAUSER WA; RISCH N;
Indirizzi:
COLUMBIA UNIV,GH SERGIEVSKY CTR,630 W 168TH ST NEW YORK NY 10032 COLUMBIA UNIV,SCH PUBL HLTH,DIV EPIDEMIOL NEW YORK NY 10032 NEW YORK STATE PSYCHIAT INST & HOSP,EPIDEMIOL BRAIN DISORDERS RES DEPT NEW YORK NY 00000 COLUMBIA UNIV,DEPT NEUROL NEW YORK NY 00000 YALE UNIV,SCH MED,DEPT GENET NEW HAVEN CT 06510 YALE UNIV,SCH MED,DEPT EPIDEMIOL & PUBL HLTH NEW HAVEN CT 06510
Titolo Testata:
American journal of epidemiology
fascicolo: 3, volume: 141, anno: 1995,
pagine: 235 - 241
SICI:
0002-9262(1995)141:3<235:BCAFRO>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
SEIZURE DISORDERS; RELATIVES; ROCHESTER; MINNESOTA; TRENDS; RATES;
Keywords:
COHORT EFFECT; EPILEPSY; GENETICS; SEIZURES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
23
Recensione:
Indirizzi per estratti:
Citazione:
R. Ottman et al., "BIRTH COHORT AND FAMILIAL RISK OF EPILEPSY - THE EFFECT OF DIMINISHEDRECALL IN STUDIES OF LIFETIME PREVALENCE", American journal of epidemiology, 141(3), 1995, pp. 235-241

Abstract

This study separated the effects of age, birth cohort, and generation(parents, siblings, and offspring) on familial risk of epilepsy. The study population comprised 9,741 parents, siblings, and offspring of 1,957 adult probands with epilepsy ascertained from 10 voluntary organizations in New York, New Jersey, Connecticut, and Massachusetts between 1985 and 1988. Semistructured telephone interviews with probands andselected family members were used to collect data on the history of epilepsy in the relatives, The risk of epilepsy increased in successivegenerations (cumulative incidence to age 40: parents, 1.8%; siblings,2.9%; offspring, 5.6%) but, with the exception of one subgroup (offspring of female probands), these differences disappeared after controlling for age and birth year of the relatives, With age and relationshipcontrolled, the risk of epilepsy increased approximately 50% for each20 advancing years of birth. Population-based data indicate that age-specific incidence rates of epilepsy have not increased during the ageand time periods investigated here; thus, the most plausible explanation for the findings is that epilepsy is underreported in persons bornin earlier time periods, These results illustrate a general phenomenon of underreporting in studies of lifetime prevalence, and they caution against interpreting apparent cohort effects in such studies as evidence of secular changes in incidence.

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Documento generato il 19/09/20 alle ore 15:11:12