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Titolo:
PRODUCTION OF ALDOSTERONE IN ISOLATED RAT-BLOOD VESSELS
Autore:
TAKEDA Y; MIYAMORI I; YONEDA T; IKI K; HATAKEYAMA H; BLAIR IA; HSIEH FY; TAKEDA R;
Indirizzi:
KANAZAWA UNIV,SCH MED,DEPT INTERNAL MED 2,13-1 TAKARA MACHI KANAZAWA ISHIKAWA 920 JAPAN KANAZAWA UNIV,SCH MED,DEPT INTERNAL MED 2 KANAZAWA ISHIKAWA 920 JAPAN VANDERBILT UNIV,SCH MED,DIV CLIN PHARMACOL,MASS SPECT RESOURCE NASHVILLE TN 00000
Titolo Testata:
Hypertension
fascicolo: 2, volume: 25, anno: 1995,
pagine: 170 - 173
SICI:
0194-911X(1995)25:2<170:POAIIR>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
CONGENITAL ADRENAL-HYPERPLASIA; RENIN-ANGIOTENSIN SYSTEM; LEYDIG-CELL TUMOR; MESSENGER-RNA; SYNTHASE CYTOCHROME-P-450; MESENTERIC-ARTERIES; CONVERTING-ENZYME; GENE-EXPRESSION; DEOXYCORTICOSTERONE; BINDING;
Keywords:
ALDOSTERONE; MESENTERIC ARTERY; RATS; ADRENALECTOMY; ANGIOTENSIN I-CONVERTING ENZYME INHIBITORS; ANGIOTENSIN II;
Tipo documento:
Note
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
27
Recensione:
Indirizzi per estratti:
Citazione:
Y. Takeda et al., "PRODUCTION OF ALDOSTERONE IN ISOLATED RAT-BLOOD VESSELS", Hypertension, 25(2), 1995, pp. 170-173

Abstract

Angiotensin I (Ang I), Ang II, angiotensinogen, and renin are formed locally in the vasculature. We undertook this study to determine whether the rat mesenteric artery produces aldosterone and to investigate the effects of adrenalectomy, an angiotensin-converting enzyme inhibitor, Ang II, or potassium on aldosterone production in vascular tissue. Isolated rat mesenteric arteries were perfused with Krebs-Ringer solution for 4 hours. The perfusate was collected and chromatographed in a reversed-phase high-performance liquid chromatographic (HPLC) system. The fraction corresponding to synthetic aldosterone was collected and analyzed by mass spectrometry. The aldosterone concentration in the perfusate from the adrenalectomized rats and rats treated with an angiotensin-converting enzyme inhibitor was measured using radioimmunoassay after HPLC separation. The mass spectra of ate of rat mesenteric arteries were identical. Aldosterone production in the mesenteric arteries of adrenalectomized rats was increased and of rats treated with an angiotensin-converting enzyme inhibitor was reduced compared with that ofcontrols. Ang II (1.9x10(-10) mol/L) and potassium (6.0 mmol/L) increased aldosterone production in mesenteric arteries. This study shows that the rat mesenteric artery produces aldosterone and that the intravascular renin-angiotensin-aldosterone system may contribute to vascular tone.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 00:32:38