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Titolo:
ISOPROTERENOL AUGMENTS ATP-EVOKED CL- SECRETION ACROSS CANINE TRACHEAL EPITHELIUM
Autore:
SATOH M; YAMAYA M; SHIMURA S; MASUDA T; YAMAMOTO M; SASAKI T; SASAKI H; SHIRATO K;
Indirizzi:
TOHOKU UNIV,SCH MED,DEPT INTERNAL MED 1,AOBA KU,1-1 SEIRYO MACHI SENDAI MIYAGI 980 JAPAN TOHOKU UNIV,SCH MED,DEPT INTERNAL MED 1,AOBA KU SENDAI MIYAGI 980 JAPAN TOHOKU UNIV,SCH MED,DEPT GERIATR MED,AOBA KU SENDAI MIYAGI 980 JAPAN
Titolo Testata:
Respiration physiology
fascicolo: 1, volume: 99, anno: 1995,
pagine: 13 - 18
SICI:
0034-5687(1995)99:1<13:IAACSA>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
EXTRACELLULAR ATP; CYSTIC-FIBROSIS; CHLORIDE SECRETION; ION-TRANSPORT; CELLS; NUCLEOTIDES; MODULATION; CHANNELS; CALCIUM;
Keywords:
CL- SECRETION, TRACHEAL EPITHELIUM; CONDUCTANCE, ELECTRICAL, TRACHEAL EPITHELIUM; EPITHELIUM, TRACHEAL, ELECTRICAL PROPERTIES; MAMMALS, DOG; TRACHEA, EPITHELIUM, ELECTRICAL PROPERTIES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
19
Recensione:
Indirizzi per estratti:
Citazione:
M. Satoh et al., "ISOPROTERENOL AUGMENTS ATP-EVOKED CL- SECRETION ACROSS CANINE TRACHEAL EPITHELIUM", Respiration physiology, 99(1), 1995, pp. 13-18

Abstract

Using an Ussing chamber, both the posterior epithelial membrane and cultured epithelial cell monolayers from canine trachea were used for measurements of potential difference (PD) and short circuit current (SCC). Conductance (G) was calculated as the ratio SCC/PD. Adenosine (10(-5) to 10(-3) M) failed to produce any significant increases in PD andSCC. ATP (10(-6) to 10(-4) M) produced a significant transient increase in SCC in a dose-dependent fashion, reaching a peak value within 3 min after stimulation. Isoproterenol (ISOP) at 10(-8) M itself did notsignificantly alter the SCC value. In both the epithelial membrane and cultured epithelial cells treated with amiloride, however, pretreatment with 10(-8) M ISOP significantly augmented the ATP-induced SCC rise, whereas G did not significantly change. These findings indicate that beta-adrenergic stimulation augments Cl- secretion induced by P-2-receptor stimulation in airway epithelial cells.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/07/20 alle ore 01:47:07