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Titolo:
NITRIC OXIDE-RELATED SPECIES INHIBIT EVOKED NEUROTRANSMISSION BUT ENHANCE SPONTANEOUS MINIATURE SYNAPTIC CURRENTS IN CENTRAL NEURONAL CULTURES
Autore:
PAN ZH; SEGAL MM; LIPTON SA;
Indirizzi:
CHILDRENS HOSP,DEPT NEUROL,MOL & CELLULAR NEUROSCI LAB,ENDERS BLDG,ROOM 361,300 LONGWOOD AVE BOSTON MA 02115 CHILDRENS HOSP,DEPT NEUROL,MOL & CELLULAR NEUROSCI LAB BOSTON MA 02115 HARVARD UNIV,SCH MED,PROGRAM NEUROSCI BOSTON MA 02115
Titolo Testata:
Proceedings of the National Academy of Sciences of the United Statesof America
fascicolo: 26, volume: 93, anno: 1996,
pagine: 15423 - 15428
SICI:
0027-8424(1996)93:26<15423:NOSIEN>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
LONG-TERM POTENTIATION; HIPPOCAMPAL-NEURONS; NMDA RECEPTOR; TRANSMITTER RELEASE; INTERCELLULAR MESSENGER; EXCITATORY SYNAPSES; NITROGEN-DIOXIDE; SYNAPTOTAGMIN-I; DEPRESSION; SLICES;
Keywords:
EXCITATORY POSTSYNAPTIC CURRENTS; GLUTAMATE RECEPTORS; NITROSONIUM DONORS; REDOX; SPONTANEOUS MINIATURE EXCITATORY POSTSYNAPTIC CURRENTS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
69
Recensione:
Indirizzi per estratti:
Citazione:
Z.H. Pan et al., "NITRIC OXIDE-RELATED SPECIES INHIBIT EVOKED NEUROTRANSMISSION BUT ENHANCE SPONTANEOUS MINIATURE SYNAPTIC CURRENTS IN CENTRAL NEURONAL CULTURES", Proceedings of the National Academy of Sciences of the United Statesof America, 93(26), 1996, pp. 15423-15428

Abstract

Nitric oxide (NO.) does not react significantly with thiol groups under physiological conditions, whereas a variety of endogenous NO donor molecules facilitate rapid transfer to thiol of nitrosonium ion (NO+, with one less electron than NO.). Here, nitrosonium donors are shown to decrease the efficacy of evoked neurotransmission while increasing the frequency of spontaneous miniature excitatory postsynaptic currents(mEPSCs). In contrast, pure NO. donors have little effect (displayingat most only a slight increase) on the amplitude of evoked EPSCs and frequency of spontaneous mEPSCs in our preparations. These findings may help explain heretofore paradoxical observations that the NO moiety can either increase, decrease, or have no net effect on synaptic activity in various preparations.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/07/20 alle ore 17:51:01