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Titolo:
DELAYED MATURATION OF THE FRONTAL-CORTEX IN CHILDHOOD AUTISM
Autore:
ZILBOVICIUS M; GARREAU B; SAMSON Y; REMY P; BARTHELEMY C; SYROTA A; LELORD G;
Indirizzi:
CEA,SERV HOSP FREDERIC JOLIOT,4 PL GEN LECLERC F-91406 ORSAY FRANCE INSERM TOURS FRANCE
Titolo Testata:
The American journal of psychiatry
fascicolo: 2, volume: 152, anno: 1995,
pagine: 248 - 252
SICI:
0002-953X(1995)152:2<248:DMOTFI>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
CEREBRAL BLOOD-FLOW; POSITRON EMISSION TOMOGRAPHY; GLUCOSE-UTILIZATION; INFANTILE-AUTISM; BRAIN; METABOLISM; INDIVIDUALS; CHILDREN; MONKEYS; MIND;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Science Citation Index Expanded
Citazioni:
39
Recensione:
Indirizzi per estratti:
Citazione:
M. Zilbovicius et al., "DELAYED MATURATION OF THE FRONTAL-CORTEX IN CHILDHOOD AUTISM", The American journal of psychiatry, 152(2), 1995, pp. 248-252

Abstract

Objective: The authors investigated the metabolic maturation of the frontal cortex in preschool autistic children. Method: Regional cerebral blood flow (CBF) in five children with primary autism diagnosed according to the DSM-III-R criteria was studied longitudinally. Regional CBF in each of the autistic children was measured with single photon emission computed tomography twice during their development: at the age of 3-4 years and 3 years later. At each stage, the autistic children were compared to an age-matched comparison group of five nonautistic children with normal development. Results: A transient frontal hypoperfusion was found in the autistic children at ages 3-4 years; this corresponded to the pattern of perfusion observed in much younger normal children. By the ages of 6-7, the autistic children's frontal perfusion had attained normal values. Conclusions: Since CBF patterns in childrenare related to maturational changes in brain function, these results indicate a delayed frontal maturation in childhood autism. Such a delayed brain maturational process is consistent with the clinical data and cognitive performance of autistic children.

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Documento generato il 23/01/20 alle ore 03:20:22