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Titolo:
PERSISTENT SPONTANEOUS ORAL DYSKINESIAS IN HALOPERIDOL-WITHDRAWN RATSNEONATALLY LESIONED WITH 6-HYDROXYDOPAMINE - ABSENCE OF AN ASSOCIATION WITH THE B-MAX FOR [H-3] RACLOPRIDE BINDING TO NEOSTRIATAL HOMOGENATES
Autore:
HUANG NY; KOSTRZEWA RM; LI CF; PERRY KW; FULLER RW;
Indirizzi:
E TENNESSEE STATE UNIV,QUILLEN COLL MED,DEPT PHARMACOL JOHNSON CITY TN 37614 E TENNESSEE STATE UNIV,QUILLEN COLL MED,DEPT PHARMACOL JOHNSON CITY TN 37614 E TENNESSEE STATE UNIV,QUILLEN COLL MED,DEPT INTERNAL MED JOHNSON CITY TN 37614 ELI LILLY & CO,LILLY RES LABS,LILLY CORP CTR INDIANAPOLIS IN 46285
Titolo Testata:
The Journal of pharmacology and experimental therapeutics
fascicolo: 1, volume: 280, anno: 1997,
pagine: 268 - 276
SICI:
0022-3565(1997)280:1<268:PSODIH>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
VACUOUS CHEWING MOVEMENTS; GLUTAMIC-ACID DECARBOXYLASE; RECEPTOR SUPER-SENSITIVITY; DEPLETING BRAIN-LESIONS; TARDIVE-DYSKINESIA; DOPAMINE-RECEPTORS; NEUROLEPTIC TREATMENT; MESSENGER-RNAS; UP-REGULATION; D2;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
71
Recensione:
Indirizzi per estratti:
Citazione:
N.Y. Huang et al., "PERSISTENT SPONTANEOUS ORAL DYSKINESIAS IN HALOPERIDOL-WITHDRAWN RATSNEONATALLY LESIONED WITH 6-HYDROXYDOPAMINE - ABSENCE OF AN ASSOCIATION WITH THE B-MAX FOR [H-3] RACLOPRIDE BINDING TO NEOSTRIATAL HOMOGENATES", The Journal of pharmacology and experimental therapeutics, 280(1), 1997, pp. 268-276

Abstract

To investigate the influence of dopamine (DA) nerves on haloperidol (HAL)-induced oral dyskinesias, rats were first injected at 3 days after birth with 6-hydroxydopamine HBr (200 mu g i.c.v., salt form; 6-OHDA) or vehicle, after desipramine HCl (20 mg/kg i.p., 1 hr) pretreatment. Two months later HAL (1.5 mg/kg/day, 2 days a week for 4 weeks, thendaily for 10 months) was added to the drinking water of half the rats. Numbers of vacuous chewing movements, recorded in 1-min increments every 10 min for 1 hr, increased from <5 to about 17 oral movements persession in intact rats, 14 weeks after instituting HAL (P < .01 vs. intact rats drinking tap water). In HAL-treated 6-OHDA-lesioned rats, oral activity increased to >30 oral movements per session (P < .01 vs. HAL-treated intact rats). These levels of oral activity persisted in intact and 6-OHDA-lesioned rats as long as HAL was administered. After 11 months of HAL treatment, but 8 or 9 days after HAL withdrawal, DA was found to be reduced 97%, whereas serotonin was increased 29% in thestriatum of 6-OHDA-lesioned rats. In HAL-treated intact and lesioned rats the B-max for DA D-2 binding sites was elevated about 70%. With reverse transcription polymerase chain reaction, the mRNA level for DA D-2L but not D-2S receptors was also found to be elevated about 70%. In a fraction of 6-OHDA-lesioned rats that were observed for 8 months after HAL withdrawal, oral activity persisted without decrement and wasnot accompanied by a change in the B-max or mRNA level for DA D-2 receptors. These findings demonstrate that in rats largely DA-denervated as neonates, long-term HAL treatment produces an unusually high numberof oral movements that persists for 8 months after HAL withdrawal andis not accompanied by an increase in DA D-2 receptor expression.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 05:58:32