Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
CARDIAC BAROREFLEX IN HYPERTENSION - ROLE OF THE HEART AND ANGIOTENSIN-II
Autore:
KORNER PI;
Indirizzi:
BAKER MED RES INST,COMMERCIAL RD PRAHRAN VIC 3181 AUSTRALIA
Titolo Testata:
Clinical and experimental hypertension
fascicolo: 1-2, volume: 17, anno: 1995,
pagine: 425 - 439
SICI:
1064-1963(1995)17:1-2<425:CBIH-R>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
RATE REFLEX; BLOOD-PRESSURE; AORTIC BARORECEPTORS; RENAL-HYPERTENSION; NERVE ACTIVITY; RATE RESPONSES; STEADY-STATE; RABBIT; SENSITIVITY; DOGS;
Keywords:
BARORECEPTOR HEART RATE REFLEX; ARTERIAL AND CARDIOPULMONARY BARORECEPTORS; CARDIAC HYPERTROPHY, REVERSIBILITY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
53
Recensione:
Indirizzi per estratti:
Citazione:
P.I. Korner, "CARDIAC BAROREFLEX IN HYPERTENSION - ROLE OF THE HEART AND ANGIOTENSIN-II", Clinical and experimental hypertension, 17(1-2), 1995, pp. 425-439

Abstract

Sigmoid logistic function curves provide a powerful means of characterizing the baroreceptor-heart rate reflex. in hypertension the operating range of the reflex is reset in the direction of the elevated resting BP; this can be accounted by rapid resetting of the threshold of the arterial baroreceptors. In addition, there is a deficit in the vagalcomponent of the heart rate (HR) range. Reduction in gain occurs in moderate/severe hypertension, but may be absent in young primary hypertensives. All the changes are reversible, and reversibility of HR rangeand gain is related to reducing left ventricular hypertrophy or central blood volume rather than to reduction in BP. High plasma angiotensin II can further accentuate the vagal deficit. An input-output model has been developed from comparison of perivascular cuff and drug methods for eliciting the reflex, which place different loads on the heart; the greater load changes simulate many of the alterations in reflex properties observed in hypertension. We conclude that during changes in vasomotor tone in normal animals, about 70% of the drive for the cardiac baroreflex comes from arterial baroreceptors and about 30% from lowthreshold cardio-pulmonary baroreceptors. In hypertension, the vagal deficit in HR range is due to afferent interactions involving arterialand low and high threshold cardio-pulmonary baroreceptors.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/11/20 alle ore 10:57:53