Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
3 TYPES OF POSTSYNAPTIC GLUTAMATERGIC RECEPTORS ARE ACTIVATED IN DMNXNEURONS UPON STIMULATION OF NTS
Autore:
WILLIS A; MIHALEVICH M; NEFF RA; MENDELOWITZ D;
Indirizzi:
UNIV TENNESSEE,CTR HLTH SCI,DEPT PHYSIOL & BIOPHYS,894 UNION AVE MEMPHIS TN 38163 UNIV TENNESSEE,CTR HLTH SCI,DEPT PHYSIOL & BIOPHYS MEMPHIS TN 38163
Titolo Testata:
American journal of physiology. Regulatory, integrative and comparative physiology
fascicolo: 6, volume: 40, anno: 1996,
pagine: 1614 - 1619
SICI:
0363-6119(1996)40:6<1614:3TOPGR>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
DORSAL MOTOR NUCLEUS; GASTRIC-ACID SECRETION; ELECTRICAL-STIMULATION; TRACTUS-SOLITARII; VAGAL MOTONEURONS; BRAIN-STEM; IN-VITRO; VAGUS; CURRENTS; HEART;
Keywords:
CYCLOTHIAZIDE; CONCANAVALIN A; CARDIOVASCULAR SYSTEM; NUCLEUS OF THE SOLITARY TRACT -ALPHA-AMINO-3-HYDROXY-5-METHYLISOXAZOLE-PROPIONIC ACID; KAINATE; N-METHYL-D-ASPARTATE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
26
Recensione:
Indirizzi per estratti:
Citazione:
A. Willis et al., "3 TYPES OF POSTSYNAPTIC GLUTAMATERGIC RECEPTORS ARE ACTIVATED IN DMNXNEURONS UPON STIMULATION OF NTS", American journal of physiology. Regulatory, integrative and comparative physiology, 40(6), 1996, pp. 1614-1619

Abstract

While it is widely accepted that parasympathetic activity plays a significant role in cardiovascular, bronchomotor, and gastrointestinal function, little is known about the synaptic control of parasympathetic vagal neurons. In this study, we identified the neurotransmitter(s) and postsynaptic responses in dorsal motor nucleus of the vagus (DMNX) neurons upon stimulation of the nucleus of the solitary tract (NTS). Neurons were visualized in rat brain stem slices, and perforated patch-clamp techniques were used to record postsynaptic currents. NTS stimulation activated glutamatergic currents. NTS stimulation activated glutamatergic currents in DMNX that were separated into N-methyl-D-aspartate (NMDA) and non-NMDA components using D-2-amino-5-phosphonovalerate and 6-cyano-7-nitroquinoxaline-2,3-dione, respectively. The non-NMDA component was further characterized using cyclothiazide and concanavalinA to block desensitization of DL-alpha-3-hydroxy-5-methylisoxazole-propionic acid (AMPA) and kainate receptors, respectively. Cyclothiazideincreased the postsynaptic amplitude, whereas concanavalin A augmented duration, suggesting kainate, but not AMPA, currents are curtailed by desensitization. High frequency stimulations did not alter synaptic efficacy. In conclusion, this study demonstrates the existence of a monosynaptic glutamatergic pathway from NTS that activates NMDA, kainate, and AMPA postsynaptic receptors in DMNX neurons.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/08/20 alle ore 07:33:38