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Titolo:
FOREBRAIN ANGIOTENSIN TYPE-1 RECEPTORS AND PARABRACHIAL SEROTONIN IN THE CONTROL OF NACL AND WATER-INTAKE
Autore:
COLOMBARI DSA; MENANI JV; JOHNSON AK;
Indirizzi:
UNIV IOWA,DEPT PSYCHOL,11 SEASHORE HALL E IOWA CITY IA 52242 UNIV IOWA,DEPT PSYCHOL IOWA CITY IA 52242 UNIV IOWA,DEPT PHARMACOL IOWA CITY IA 52242 UNIV IOWA,CTR CARDIOVASC IOWA CITY IA 52242 PAULISTA STATE UNIV,SCH DENT,DEPT PHYSIOL BR-14801903 SAO PAULO BRAZIL
Titolo Testata:
American journal of physiology. Regulatory, integrative and comparative physiology
fascicolo: 6, volume: 40, anno: 1996,
pagine: 1470 - 1476
SICI:
0363-6119(1996)40:6<1470:FATRAP>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
SALT APPETITE; SUBFORNICAL ORGAN; BLOOD-PRESSURE; RAT; NUCLEUS; DRINKING; RESPONSES; SODIUM; BRAIN; CONNECTIONS;
Keywords:
LATERAL PARABRACHIAL NUCLEUS; ANGIOTENSIN II; SALT INTAKE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
30
Recensione:
Indirizzi per estratti:
Citazione:
D.S.A. Colombari et al., "FOREBRAIN ANGIOTENSIN TYPE-1 RECEPTORS AND PARABRACHIAL SEROTONIN IN THE CONTROL OF NACL AND WATER-INTAKE", American journal of physiology. Regulatory, integrative and comparative physiology, 40(6), 1996, pp. 1470-1476

Abstract

This study investigated the roles of serotonin (5-HT) receptors in the lateral parabrachial nucleus (LPBN), and brain angiotensin type 1 (AT(1)) receptors in the intake of 0.3 M NaCl and water induced by angiotensin II (ANG II). Rats were implanted with stainless steel cannulas for injections into tho subfornical organ (SFO) and into the LPBN. Bilateral LPBN pretreatment with the nonselective serotonergic 5-HT1/5-HT2 receptor antagonist methysergide (4 mu g/200 nl) markedly enhanced 0.3 M NaCl intake induced by injections of ANG II (20 ng/200 nl) into the SFO. Pretreatment of the SFO with the AT(1) receptor antagonist losartan (1 mu g/200 nl) blocked the intake of 0.3 M NaCl induced by ANG II in combination with LPBN methysergide injections. These results suggest that serotonergic mechanisms associated with the LPBN inhibit theexpression of salt appetite induced by ANG II injections into Ihs SFO. In addition, the results indicate that the enhanced NaCl intake generated by central administration of ANG II in the presence of LPBN 5-HTblockade is mediated bg brain ATI receptors.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 16:11:49