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Titolo:
INDEPENDENT CORRELATION BETWEEN PLASMA LIPOPROTEIN(A) AND ANGIOGRAPHIC CORONARY-ARTERY DISEASE IN NIDDM
Autore:
WATTS GF; APGWILYM RM; MAZURKIEWICZ J; COLTART J;
Indirizzi:
ROYAL PERTH HOSP,UNIV DEPT MED,BOX X2213 GPO PERTH WA 6001 AUSTRALIA UNITED MED & DENT SCH,DEPT CHEM PATHOL LONDON SE1 9RT ENGLAND UNITED MED & DENT SCH,DEPT CARDIOL LONDON SE1 9RT ENGLAND
Titolo Testata:
Diabetes care
fascicolo: 2, volume: 18, anno: 1995,
pagine: 234 - 236
SICI:
0149-5992(1995)18:2<234:ICBPLA>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
DEPENDENT DIABETIC-PATIENTS; APOLIPOPROTEIN; ASSOCIATION; LP(A);
Tipo documento:
Note
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
14
Recensione:
Indirizzi per estratti:
Citazione:
G.F. Watts et al., "INDEPENDENT CORRELATION BETWEEN PLASMA LIPOPROTEIN(A) AND ANGIOGRAPHIC CORONARY-ARTERY DISEASE IN NIDDM", Diabetes care, 18(2), 1995, pp. 234-236

Abstract

OBJECTIVE- To examine the correlation between angiographic coronary artery disease (CAD) and plasma lipoprotein(a) [Lp(a)] concentration innon-insulin-dependent diabetes mellitus (NIDDM). RESEARCH DESIGN AND METHODS- In this cross-sectional study of 36 patients with NIDDM who underwent coronary angiography, CAD was assessed visually using a coronary artery score (GAS), and plasma Lp(a) was measured immunoturbidimetrically. RESULTS- Lp(a) concentration was significantly higher in patients in the middle and upper tertiles of CASs (>4) compared with thosein the lower tertile (less than or equal to 4), geometric mean 0.30 g/l (95% confidence interval [CI] 0.22-0.40) vs. 0.12 g/l (0.08-0.17, P= 0.002). Lp(a) was significantly and positively correlated with the CAS (R(2) 23%, P = 0.006), independent of other cardiovascular risk factors, including lipoprotein related variables and glycated hemoglobin. CONCLUSIONS- Plasma Lp(a) is a strong and independent correlate of the extent of angiographic CAD in symptomatic patients with NIDDM.

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Documento generato il 20/09/20 alle ore 07:59:36